CDKN3
Summary: The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase inhibitor 3 | MIM:123832 | Ensembl:ENSG00000100526 | HGNC:HGNC:1791 | PA26324 | 14q22.2 |
GO terms in CDKN3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IBA | GO:0007050 | cell cycle arrest |
| BP | IDA | GO:0007050 | cell cycle arrest |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| MF | IBA | GO:0004722 | protein serine/threonine phosphatase activity |
| MF | IDA | GO:0004722 | protein serine/threonine phosphatase activity |
| MF | IBA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IDA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
Gene expression in normal tissue: CDKN3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDKN3
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDKN3
CLASSFICATION
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