Summary: This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].

chloride voltage-gated channel 3MIM:600580Ensembl:ENSG00000109572HGNC:HGNC:2021PA265484q33

GO terms in CLCN3

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005247voltage-gated chloride channel activity
MFIDAGO:0005254chloride channel activity
MFTASGO:0005254chloride channel activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0015297antiporter activity
MFIBAGO:0015299solute:proton antiporter activity
MFIDAGO:0030165PDZ domain binding
MFIBAGO:0031404chloride ion binding
MFNASGO:0042803protein homodimerization activity
MFIDAGO:0046982protein heterodimerization activity
MFIMPGO:0072320volume-sensitive chloride channel activity
CCIEAGO:0000139Golgi membrane
CCIBAGO:0005769early endosome
CCIDAGO:0005769early endosome
CCIDAGO:0005770late endosome
CCIBAGO:0005794Golgi apparatus
CCIDAGO:0005794Golgi apparatus
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIBAGO:0008021synaptic vesicle
CCIDAGO:0008021synaptic vesicle
CCIDAGO:0009897external side of plasma membrane
CCNASGO:0009986cell surface
CCIDAGO:0012506vesicle membrane
CCTASGO:0016021integral component of membrane
CCIDAGO:0030141secretory granule
CCIEAGO:0030658transport vesicle membrane
CCIDAGO:0031410cytoplasmic vesicle
CCIEAGO:0031901early endosome membrane
CCIEAGO:0031902late endosome membrane
CCIDAGO:0042581specific granule
CCIDAGO:0045335phagocytic vesicle
BPTASGO:0006885regulation of pH
BPIMPGO:0045794negative regulation of cell volume
BPTASGO:0048388endosomal lumen acidification
BPIBAGO:0097401synaptic vesicle lumen acidification
BPIDAGO:1902476chloride transmembrane transport

Gene expression in normal tissue: CLCN3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CLCN3

DatabasePathway IDPathway Des.
reactomeR-HSA-2672351Stimuli-sensing channels
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CLCN3