CPOX
Summary: The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).[provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| coproporphyrinogen oxidase | MIM:612732 | Ensembl:ENSG00000080819 | HGNC:HGNC:2321 | PA134979958 | 3q11.2 |
GO terms in CPOX
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004109 | coproporphyrinogen oxidase activity |
| MF | TAS | GO:0004109 | coproporphyrinogen oxidase activity |
| MF | IEA | GO:0005212 | structural constituent of eye lens |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| BP | IEA | GO:0006782 | protoporphyrinogen IX biosynthetic process |
| BP | TAS | GO:0006783 | heme biosynthetic process |
| BP | IEA | GO:0010039 | response to iron ion |
| BP | IEA | GO:0010288 | response to lead ion |
| BP | IEA | GO:0017085 | response to insecticide |
| BP | IBA | GO:0019353 | protoporphyrinogen IX biosynthetic process from glutamate |
| BP | IEA | GO:0046685 | response to arsenic-containing substance |
| BP | IEA | GO:0051597 | response to methylmercury |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005743 | mitochondrial inner membrane |
| CC | TAS | GO:0005758 | mitochondrial intermembrane space |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
Gene expression in normal tissue: CPOX
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CPOX
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00024 | Porphyrin Metabolism |
| smpdb | SMP00342 | Hereditary Coproporphyria (HCP) |
| smpdb | SMP00344 | Acute Intermittent Porphyria |
| smpdb | SMP00345 | Congenital Erythropoietic Porphyria (CEP) or Gunther Disease |
| smpdb | SMP00346 | Porphyria Variegata (PV) |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP561 | Heme Biosynthesis |
| kegg | hsa00860 | Porphyrin and chlorophyll metabolism - Homo sapiens (human) |
| humancyc | HEME-BIOSYNTHESIS-II | heme biosynthesis from uroporphyrinogen-III I |
| humancyc | PWY-5920 | heme biosynthesis |
| biocarta | ahsppathway | hemoglobins chaperone |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-189445 | Metabolism of porphyrins |
| reactome | R-HSA-189451 | Heme biosynthesis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CPOX
CLASSFICATION
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