CREB3L3


Summary: This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cAMP responsive element binding protein 3 like 3MIM:611998Ensembl:ENSG00000060566HGNC:HGNC:18855PA13488216119p13.3

GO terms in CREB3L3


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000976transcription regulatory region sequence-specific DNA binding
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIMPGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0035497cAMP response element binding
MFIDAGO:0042803protein homodimerization activity
MFIPIGO:0046982protein heterodimerization activity
CCTASGO:0000139Golgi membrane
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005783endoplasmic reticulum
CCTASGO:0005789endoplasmic reticulum membrane
CCTASGO:0005829cytosol
CCISSGO:0016020membrane
CCIEAGO:0016021integral component of membrane
BPNASGO:0002675positive regulation of acute inflammatory response
BPIEAGO:0006366transcription by RNA polymerase II
BPTASGO:0030968endoplasmic reticulum unfolded protein response
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Gene expression in normal tissue: CREB3L3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CREB3L3


DatabasePathway IDPathway Des.
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04927Cortisol synthesis and secretion - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa04962Vasopressin-regulated water reabsorption - Homo sapiens (human)
kegghsa05016Huntington,s disease - Homo sapiens (human)
kegghsa05030Cocaine addiction - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05034Alcoholism - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP45G1 to S cell cycle control
reactomeR-HSA-174824Plasma lipoprotein assembly, remodeling, and clearance
reactomeR-HSA-381119Unfolded Protein Response (UPR)
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-8874211CREB3 factors activate genes
reactomeR-HSA-8963889Assembly of active LPL and LIPC lipase complexes
reactomeR-HSA-8963899Plasma lipoprotein remodeling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD491TAE-6841

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CREB3L3

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