CREB3L4


Summary: This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cAMP responsive element binding protein 3 like 4MIM:607138Ensembl:ENSG00000143578HGNC:HGNC:18854PA1349229191q21.3

GO terms in CREB3L4


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIEAGO:0035497cAMP response element binding
BPIEAGO:0006366transcription by RNA polymerase II
BPIEAGO:0007283spermatogenesis
BPIEAGO:0030968endoplasmic reticulum unfolded protein response
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
CCIEAGO:0000139Golgi membrane
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005739mitochondrion
CCIDAGO:0005783endoplasmic reticulum
CCIEAGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005794Golgi apparatus
CCIEAGO:0016021integral component of membrane
CCIDAGO:0031965nuclear membrane

Gene expression in normal tissue: CREB3L4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CREB3L4


DatabasePathway IDPathway Des.
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP45G1 to S cell cycle control
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04927Cortisol synthesis and secretion - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa04962Vasopressin-regulated water reabsorption - Homo sapiens (human)
kegghsa05016Huntington,s disease - Homo sapiens (human)
kegghsa05030Cocaine addiction - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05034Alcoholism - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
reactomeR-HSA-381119Unfolded Protein Response (UPR)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-8874211CREB3 factors activate genes

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD134Sorafenib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CREB3L4

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