CRHBP


Summary: Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
corticotropin releasing hormone binding proteinMIM:122559Ensembl:ENSG00000145708HGNC:HGNC:2356PA268735q13.3

GO terms in CRHBP


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCISSGO:0005622intracellular
CCISSGO:0005634nucleus
CCISSGO:0005767secondary lysosome
CCISSGO:0005771multivesicular body
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0005794Golgi apparatus
CCISSGO:0005874microtubule
CCIBAGO:0030141secretory granule
CCIDAGO:0030141secretory granule
CCISSGO:0030425dendrite
CCISSGO:0031045dense core granule
CCISSGO:0043196varicosity
CCISSGO:0043204perikaryon
CCISSGO:0043679axon terminus
BPISSGO:0001963synaptic transmission, dopaminergic
BPIEAGO:0002125maternal aggressive behavior
BPIDAGO:0006954inflammatory response
BPTASGO:0007165signal transduction
BPIBAGO:0007565female pregnancy
BPIDAGO:0007565female pregnancy
BPIEPGO:0007565female pregnancy
BPTASGO:0007611learning or memory
BPIBAGO:0009755hormone-mediated signaling pathway
BPIDAGO:0009755hormone-mediated signaling pathway
BPISSGO:0035690cellular response to drug
BPIDAGO:0035865cellular response to potassium ion
BPIBAGO:0042445hormone metabolic process
BPIEAGO:0042445hormone metabolic process
BPIDAGO:0045055regulated exocytosis
BPIMPGO:0048149behavioral response to ethanol
BPIDAGO:0051459regulation of corticotropin secretion
BPIBAGO:0051460negative regulation of corticotropin secretion
BPIDAGO:0051460negative regulation of corticotropin secretion
BPISSGO:0071277cellular response to calcium ion
BPISSGO:0071314cellular response to cocaine
BPISSGO:0071320cellular response to cAMP
BPIDAGO:0071356cellular response to tumor necrosis factor
BPIDAGO:0071391cellular response to estrogen stimulus
BPIDAGO:0071392cellular response to estradiol stimulus
BPIMPGO:0080135regulation of cellular response to stress
BPISSGO:0097211cellular response to gonadotropin-releasing hormone
BPIBAGO:1900011negative regulation of corticotropin-releasing hormone receptor activity
BPIDAGO:1900011negative regulation of corticotropin-releasing hormone receptor activity
BPISSGO:2000310regulation of NMDA receptor activity
MFIPIGO:0005515protein binding
MFISSGO:0042277peptide binding
MFIBAGO:0051424corticotropin-releasing hormone binding
MFIDAGO:0051424corticotropin-releasing hormone binding
MFIPIGO:0051424corticotropin-releasing hormone binding

Gene expression in normal tissue: CRHBP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CRHBP


DatabasePathway IDPathway Des.
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
netpathPathway_CRHCRH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373080Class B/2 (Secretin family receptors)
reactomeR-HSA-500792GPCR ligand binding

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD536PLX-47201

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CRHBP

​​​​