CRHBP
Summary: Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| corticotropin releasing hormone binding protein | MIM:122559 | Ensembl:ENSG00000145708 | HGNC:HGNC:2356 | PA26873 | 5q13.3 |
GO terms in CRHBP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | ISS | GO:0005622 | intracellular |
| CC | ISS | GO:0005634 | nucleus |
| CC | ISS | GO:0005767 | secondary lysosome |
| CC | ISS | GO:0005771 | multivesicular body |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | ISS | GO:0005874 | microtubule |
| CC | IBA | GO:0030141 | secretory granule |
| CC | IDA | GO:0030141 | secretory granule |
| CC | ISS | GO:0030425 | dendrite |
| CC | ISS | GO:0031045 | dense core granule |
| CC | ISS | GO:0043196 | varicosity |
| CC | ISS | GO:0043204 | perikaryon |
| CC | ISS | GO:0043679 | axon terminus |
| BP | ISS | GO:0001963 | synaptic transmission, dopaminergic |
| BP | IEA | GO:0002125 | maternal aggressive behavior |
| BP | IDA | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007565 | female pregnancy |
| BP | IDA | GO:0007565 | female pregnancy |
| BP | IEP | GO:0007565 | female pregnancy |
| BP | TAS | GO:0007611 | learning or memory |
| BP | IBA | GO:0009755 | hormone-mediated signaling pathway |
| BP | IDA | GO:0009755 | hormone-mediated signaling pathway |
| BP | ISS | GO:0035690 | cellular response to drug |
| BP | IDA | GO:0035865 | cellular response to potassium ion |
| BP | IBA | GO:0042445 | hormone metabolic process |
| BP | IEA | GO:0042445 | hormone metabolic process |
| BP | IDA | GO:0045055 | regulated exocytosis |
| BP | IMP | GO:0048149 | behavioral response to ethanol |
| BP | IDA | GO:0051459 | regulation of corticotropin secretion |
| BP | IBA | GO:0051460 | negative regulation of corticotropin secretion |
| BP | IDA | GO:0051460 | negative regulation of corticotropin secretion |
| BP | ISS | GO:0071277 | cellular response to calcium ion |
| BP | ISS | GO:0071314 | cellular response to cocaine |
| BP | ISS | GO:0071320 | cellular response to cAMP |
| BP | IDA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IDA | GO:0071391 | cellular response to estrogen stimulus |
| BP | IDA | GO:0071392 | cellular response to estradiol stimulus |
| BP | IMP | GO:0080135 | regulation of cellular response to stress |
| BP | ISS | GO:0097211 | cellular response to gonadotropin-releasing hormone |
| BP | IBA | GO:1900011 | negative regulation of corticotropin-releasing hormone receptor activity |
| BP | IDA | GO:1900011 | negative regulation of corticotropin-releasing hormone receptor activity |
| BP | ISS | GO:2000310 | regulation of NMDA receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0042277 | peptide binding |
| MF | IBA | GO:0051424 | corticotropin-releasing hormone binding |
| MF | IDA | GO:0051424 | corticotropin-releasing hormone binding |
| MF | IPI | GO:0051424 | corticotropin-releasing hormone binding |
Gene expression in normal tissue: CRHBP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CRHBP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| netpath | Pathway_CRH | CRH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373080 | Class B/2 (Secretin family receptors) |
| reactome | R-HSA-500792 | GPCR ligand binding |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CRHBP
CLASSFICATION
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