CST5
Summary: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cystatin D | MIM:123858 | Ensembl:ENSG00000170367 | HGNC:HGNC:2477 | PA26978 | 20p11.21 |
GO terms in CST5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IDA | GO:0004869 | cysteine-type endopeptidase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: CST5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CST5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| wikipathways | WP474 | Endochondral Ossification |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CST5
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