CUL5
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cullin 5 | MIM:601741 | Ensembl:ENSG00000166266 | HGNC:HGNC:2556 | PA27052 | 11q22.3 |
GO terms in CUL5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0031461 | cullin-RING ubiquitin ligase complex |
| CC | IBA | GO:0031466 | Cul5-RING ubiquitin ligase complex |
| CC | IDA | GO:0031466 | Cul5-RING ubiquitin ligase complex |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IEA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | TAS | GO:0038128 | ERBB2 signaling pathway |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | IEA | GO:0070588 | calcium ion transmembrane transport |
| BP | TAS | GO:0097193 | intrinsic apoptotic signaling pathway |
| MF | TAS | GO:0004842 | ubiquitin-protein transferase activity |
| MF | TAS | GO:0005262 | calcium channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0031625 | ubiquitin protein ligase binding |
| MF | IDA | GO:0031625 | ubiquitin protein ligase binding |
| MF | TAS | GO:0038023 | signaling receptor activity |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
Gene expression in normal tissue: CUL5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CUL5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-180585 | Vif-mediated degradation of APOBEC3G |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8863795 | Downregulation of ERBB2 signaling |
| reactome | R-HSA-8951664 | Neddylation |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP3300 | Dual hijack model of Vif in HIV infection |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CUL5
CLASSFICATION
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