CYP2S1


Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cytochrome P450 family 2 subfamily S member 1MIM:611529Ensembl:ENSG00000167600HGNC:HGNC:15654PA2711319q13.2

GO terms in CYP2S1


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005737cytoplasm
CCIDAGO:0005783endoplasmic reticulum
CCTASGO:0005789endoplasmic reticulum membrane
CCIEAGO:0031090organelle membrane
CCIBAGO:0043231intracellular membrane-bounded organelle
BPIBAGO:0006082organic acid metabolic process
BPIBAGO:0006805xenobiotic metabolic process
BPIBAGO:0042738exogenous drug catabolic process
BPIBAGO:0055114oxidation-reduction process
BPIEAGO:0055114oxidation-reduction process
MFIEAGO:0005506iron ion binding
MFIPIGO:0005515protein binding
MFIBAGO:0008392arachidonic acid epoxygenase activity
MFIBAGO:0008395steroid hydroxylase activity
MFTASGO:0008401retinoic acid 4-hydroxylase activity
MFIBAGO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
MFIBAGO:0020037heme binding
MFIEAGO:0020037heme binding
MFIEAGO:0070330aromatase activity

Gene expression in normal tissue: CYP2S1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CYP2S1


DatabasePathway IDPathway Des.
kegghsa00830Retinol metabolism - Homo sapiens (human)
kegghsa00980Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)
humancycPWY-5451acetone degradation I (to methylglyoxal)
humancycPWY-6398melatonin degradation I
humancycPWY-6402superpathway of melatonin degradation
humancycPWY66-201nicotine degradation IV
humancycPWY66-221nicotine degradation III
humancycPWY66-241bupropion degradation
humancycPWY66-401superpathway of tryptophan utilization
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP43Oxidation by Cytochrome P450
wikipathwaysWP702Metapathway biotransformation Phase I and II
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-211859Biological oxidations
reactomeR-HSA-211897Cytochrome P450 - arranged by substrate type
reactomeR-HSA-211945Phase I - Functionalization of compounds
reactomeR-HSA-211958Miscellaneous substrates
reactomeR-HSA-211981Xenobiotics
reactomeR-HSA-211999CYP2E1 reactions

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD131Erlotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CYP2S1

​​​​