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DCAF6

Summary: The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
DDB1 and CUL4 associated factor 6	MIM:610494	Ensembl:ENSG00000143164	HGNC:HGNC:30002	PA165751150	1q24.2

GO terms in DCAF6

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0030374	nuclear receptor transcription coactivator activity
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0005829	cytosol
CC	IDA	GO:0005925	focal adhesion
CC	IDA	GO:0080008	Cul4-RING E3 ubiquitin ligase complex
BP	IEA	GO:0016567	protein ubiquitination
BP	TAS	GO:0043687	post-translational protein modification
BP	IGI	GO:0045944	positive regulation of transcription by RNA polymerase II

Gene expression in normal tissue: DCAF6

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DCAF6

Database	Pathway ID	Pathway Des.
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-597592	Post-translational protein modification
reactome	R-HSA-8951664	Neddylation

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD536	PLX-4720	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DCAF6

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DATATYPES

CLASSFICATION

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