DCAF6


Summary: The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DDB1 and CUL4 associated factor 6MIM:610494Ensembl:ENSG00000143164HGNC:HGNC:30002PA1657511501q24.2

GO terms in DCAF6


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIDAGO:0030374nuclear receptor transcription coactivator activity
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCIDAGO:0005925focal adhesion
CCIDAGO:0080008Cul4-RING E3 ubiquitin ligase complex
BPIEAGO:0016567protein ubiquitination
BPTASGO:0043687post-translational protein modification
BPIGIGO:0045944positive regulation of transcription by RNA polymerase II

Gene expression in normal tissue: DCAF6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DCAF6


DatabasePathway IDPathway Des.
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8951664Neddylation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD536PLX-47202

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DCAF6

​​​​