DCAF6
Summary: The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
DDB1 and CUL4 associated factor 6 | MIM:610494 | Ensembl:ENSG00000143164 | HGNC:HGNC:30002 | PA165751150 | 1q24.2 |
GO terms in DCAF6
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
MF | IDA | GO:0030374 | nuclear receptor transcription coactivator activity |
CC | IDA | GO:0005634 | nucleus |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005829 | cytosol |
CC | IDA | GO:0005925 | focal adhesion |
CC | IDA | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex |
BP | IEA | GO:0016567 | protein ubiquitination |
BP | TAS | GO:0043687 | post-translational protein modification |
BP | IGI | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Gene expression in normal tissue: DCAF6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DCAF6
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-597592 | Post-translational protein modification |
reactome | R-HSA-8951664 | Neddylation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DCAF6