DHX9


Summary: This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DExH-box helicase 9MIM:603115Ensembl:ENSG00000135829HGNC:HGNC:2750PA272321q25.3

GO terms in DHX9


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0000993RNA polymerase II core binding
MFIDAGO:0001069regulatory region RNA binding
MFIPIGO:0001085RNA polymerase II transcription factor binding
MFISSGO:0003677DNA binding
MFIDAGO:0003688DNA replication origin binding
MFIDAGO:0003690double-stranded DNA binding
MFIDAGO:0003697single-stranded DNA binding
MFIMPGO:0003712transcription coregulator activity
MFIMPGO:0003713transcription coactivator activity
MFHDAGO:0003723RNA binding
MFIDAGO:0003723RNA binding
MFTASGO:0003724RNA helicase activity
MFIDAGO:0003725double-stranded RNA binding
MFIDAGO:0003727single-stranded RNA binding
MFIDAGO:0003729mRNA binding
MFIMPGO:0003729mRNA binding
MFIBAGO:0004003ATP-dependent DNA helicase activity
MFIMPGO:0004003ATP-dependent DNA helicase activity
MFIDAGO:0004004ATP-dependent RNA helicase activity
MFISSGO:0004004ATP-dependent RNA helicase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIMPGO:0016887ATPase activity
MFISSGO:0016887ATPase activity
MFISSGO:0017111nucleoside-triphosphatase activity
MFIDAGO:0031490chromatin DNA binding
MFIDAGO:0033681ATP-dependent 3'-5' DNA/RNA helicase activity
MFIBAGO:0034459ATP-dependent 3'-5' RNA helicase activity
MFIDAGO:0034459ATP-dependent 3'-5' RNA helicase activity
MFIDAGO:0035197siRNA binding
MFIDAGO:0035613RNA stem-loop binding
MFIBAGO:0043140ATP-dependent 3'-5' DNA helicase activity
MFIDAGO:0043140ATP-dependent 3'-5' DNA helicase activity
MFISSGO:0043140ATP-dependent 3'-5' DNA helicase activity
MFIDAGO:0045142triplex DNA binding
MFIEAGO:0046872metal ion binding
MFIDAGO:0047429nucleoside-triphosphate diphosphatase activity
MFIDAGO:0061676importin-alpha family protein binding
MFIDAGO:0070063RNA polymerase binding
MFIDAGO:1905172RISC complex binding
MFIDAGO:1905538polysome binding
MFIDAGO:1990518single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity
MFIDAGO:1990825sequence-specific mRNA binding
MFIMPGO:1990841promoter-specific chromatin binding
BPIMPGO:0000380alternative mRNA splicing, via spliceosome
BPTASGO:0000398mRNA splicing, via spliceosome
BPHDAGO:0001649osteoblast differentiation
BPIEAGO:0006260DNA replication
BPIEAGO:0006353DNA-templated transcription, termination
BPIMPGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006954inflammatory response
BPIDAGO:0010501RNA secondary structure unwinding
BPIMPGO:0030423targeting of mRNA for destruction involved in RNA interference
BPTASGO:0032481positive regulation of type I interferon production
BPIDAGO:0032508DNA duplex unwinding
BPIMPGO:0032508DNA duplex unwinding
BPISSGO:0032508DNA duplex unwinding
BPISSGO:0032741positive regulation of interleukin-18 production
BPIMPGO:0035549positive regulation of interferon-beta secretion
BPIDAGO:0039695DNA-templated viral transcription
BPIDAGO:0044806G-quadruplex DNA unwinding
BPIEAGO:0045087innate immune response
BPISSGO:0045089positive regulation of innate immune response
BPIMPGO:0045739positive regulation of DNA repair
BPIMPGO:0045740positive regulation of DNA replication
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046833positive regulation of RNA export from nucleus
BPIMPGO:0048146positive regulation of fibroblast proliferation
BPIEAGO:0048511rhythmic process
BPIDAGO:0050434positive regulation of viral transcription
BPIBAGO:0050684regulation of mRNA processing
BPIDAGO:0050684regulation of mRNA processing
BPISSGO:0050691regulation of defense response to virus by host
BPISSGO:0050729positive regulation of inflammatory response
BPIEAGO:0051028mRNA transport
BPIMPGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIMPGO:0060760positive regulation of response to cytokine stimulus
BPISSGO:0070269pyroptosis
BPIMPGO:0070922small RNA loading onto RISC
BPIMPGO:0070934CRD-mediated mRNA stabilization
BPIMPGO:0071356cellular response to tumor necrosis factor
BPIMPGO:0071360cellular response to exogenous dsRNA
BPIMPGO:1902741positive regulation of interferon-alpha secretion
BPIMPGO:1903608protein localization to cytoplasmic stress granule
BPIMPGO:1904469positive regulation of tumor necrosis factor secretion
BPIMPGO:1904973positive regulation of viral translation
BPIMPGO:1905698positive regulation of polysome binding
BPIMPGO:2000373positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
BPIMPGO:2000637positive regulation of gene silencing by miRNA
BPIDAGO:2000765regulation of cytoplasmic translation
BPIMPGO:2000767positive regulation of cytoplasmic translation
BPIMPGO:2000778positive regulation of interleukin-6 secretion
CCIBAGO:0005622intracellular
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005726perichromatin fibrils
CCIBAGO:0005730nucleolus
CCIEAGO:0005730nucleolus
CCIDAGO:0005737cytoplasm
CCIDAGO:0005813centrosome
CCTASGO:0005829cytosol
CCIDAGO:0005844polysome
CCIDAGO:0015629actin cytoskeleton
CCHDAGO:0016020membrane
CCIDAGO:0016604nuclear body
CCIDAGO:0032991protein-containing complex
CCIDAGO:0035068micro-ribonucleoprotein complex
CCIDAGO:0036464cytoplasmic ribonucleoprotein granule
CCIDAGO:0042788polysomal ribosome
CCIMPGO:0070578RISC-loading complex
CCIDAGO:0070937CRD-mediated mRNA stability complex
CCIDAGO:0097165nuclear stress granule
CCIMPGO:0097165nuclear stress granule
CCIDAGO:1990904ribonucleoprotein complex
CCIMPGO:1990904ribonucleoprotein complex

Gene expression in normal tissue: DHX9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DHX9


DatabasePathway IDPathway Des.
reactomeR-HSA-1606322ZBP1(DAI) mediated induction of type I IFNs
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-1810476RIP-mediated NFkB activation via ZBP1
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-3134963DEx/H-box helicases activate type I IFN and inflammatory cytokines production
reactomeR-HSA-72163mRNA Splicing - Major Pathway
reactomeR-HSA-72172mRNA Splicing
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-8953854Metabolism of RNA
wikipathwaysWP411mRNA Processing

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD63Camptothecin1
iGMDRD371THR1 Inhibitor1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DHX9

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