Summary: The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 2, 6, 10, 14 and 19. [provided by RefSeq, Jan 2012].

DnaJ heat shock protein family (Hsp40) member C19MIM:608977Ensembl:ENSG00000205981HGNC:HGNC:30528PA1426719673q26.33

GO terms in DNAJC19

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0001671ATPase activator activity
MFIPIGO:0005515protein binding
MFIBAGO:0008565protein transporter activity
CCIBAGO:0001405presequence translocase-associated import motor
CCIDAGO:0005743mitochondrial inner membrane
CCNASGO:0016021integral component of membrane
CCIDAGO:0032991protein-containing complex
BPNASGO:0006457protein folding
BPNASGO:0006626protein targeting to mitochondrion
BPIMPGO:0007601visual perception
BPIBAGO:0030150protein import into mitochondrial matrix
BPIMPGO:0048806genitalia development

Gene expression in normal tissue: DNAJC19

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DNAJC19

DatabasePathway IDPathway Des.
reactomeR-HSA-1268020Mitochondrial protein import
reactomeR-HSA-392499Metabolism of proteins

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DNAJC19