Summary: The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016].

ectodysplasin A2 receptorMIM:300276Ensembl:ENSG00000131080HGNC:HGNC:17756PA134974675Xq12

GO terms in EDA2R

Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0005031tumor necrosis factor-activated receptor activity
MFIPIGO:0005515protein binding
MFIDAGO:0038023signaling receptor activity
BPIEAGO:0007275multicellular organism development
BPNASGO:0008544epidermis development
BPIBAGO:0009888tissue development
BPICGO:0010668ectodermal cell differentiation
BPTASGO:0033209tumor necrosis factor-mediated signaling pathway
BPIBAGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIBAGO:0046330positive regulation of JNK cascade
BPIDAGO:0046330positive regulation of JNK cascade
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIEAGO:0072332intrinsic apoptotic signaling pathway by p53 class mediator
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0005887integral component of plasma membrane
CCICGO:0016021integral component of membrane

Gene expression in normal tissue: EDA2R

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EDA2R

DatabasePathway IDPathway Des.
wikipathwaysWP2858Ectoderm Differentiation
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5669034TNFs bind their physiological receptors

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD512nutlin 31

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EDA2R