EREG


Summary: This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
epiregulinMIM:602061Ensembl:ENSG00000124882HGNC:HGNC:3443PA278564q13.3

GO terms in EREG


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000165MAPK cascade
BPIEAGO:0001525angiogenesis
BPISSGO:0001550ovarian cumulus expansion
BPISSGO:0001556oocyte maturation
BPISSGO:0001819positive regulation of cytokine production
BPISSGO:0007143female meiotic nuclear division
BPIBAGO:0007173epidermal growth factor receptor signaling pathway
BPISSGO:0007173epidermal growth factor receptor signaling pathway
BPIDAGO:0007267cell-cell signaling
BPIBAGO:0008284positive regulation of cell proliferation
BPIDAGO:0008284positive regulation of cell proliferation
BPISSGO:0008284positive regulation of cell proliferation
BPISSGO:0008285negative regulation of cell proliferation
BPIDAGO:0009299mRNA transcription
BPTASGO:0009653anatomical structure morphogenesis
BPTASGO:0009887animal organ morphogenesis
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIDAGO:0019221cytokine-mediated signaling pathway
BPTASGO:0030216keratinocyte differentiation
BPISSGO:0030728ovulation
BPTASGO:0038128ERBB2 signaling pathway
BPTASGO:0042060wound healing
BPIDAGO:0042108positive regulation of cytokine biosynthetic process
BPIDAGO:0042327positive regulation of phosphorylation
BPISSGO:0042327positive regulation of phosphorylation
BPISSGO:0042700luteinizing hormone signaling pathway
BPIEAGO:0043434response to peptide hormone
BPIDAGO:0043616keratinocyte proliferation
BPISSGO:0045089positive regulation of innate immune response
BPISSGO:0045410positive regulation of interleukin-6 biosynthetic process
BPIDAGO:0045740positive regulation of DNA replication
BPISSGO:0045740positive regulation of DNA replication
BPISSGO:0045741positive regulation of epidermal growth factor-activated receptor activity
BPISSGO:0045840positive regulation of mitotic nuclear division
BPIDAGO:0045860positive regulation of protein kinase activity
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPIDAGO:0048146positive regulation of fibroblast proliferation
BPISSGO:0048160primary follicle stage
BPISSGO:0048661positive regulation of smooth muscle cell proliferation
BPTASGO:0050680negative regulation of epithelial cell proliferation
BPIDAGO:0051151negative regulation of smooth muscle cell differentiation
BPIEAGO:0051781positive regulation of cell division
BPTASGO:0051897positive regulation of protein kinase B signaling
BPTASGO:2000145regulation of cell motility
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCIEAGO:0005622intracellular
CCTASGO:0005887integral component of plasma membrane
MFTASGO:0004713protein tyrosine kinase activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIBAGO:0005154epidermal growth factor receptor binding
MFISSGO:0005154epidermal growth factor receptor binding
MFTASGO:0005154epidermal growth factor receptor binding
MFIPIGO:0005515protein binding
MFIBAGO:0008083growth factor activity
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Gene expression in normal tissue: EREG

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EREG


DatabasePathway IDPathway Des.
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1236394Signaling by ERBB4
reactomeR-HSA-1236394Signaling by ERBB4
reactomeR-HSA-1250196SHC1 events in ERBB2 signaling
reactomeR-HSA-1250196SHC1 events in ERBB2 signaling
reactomeR-HSA-1250342PI3K events in ERBB4 signaling
reactomeR-HSA-1250347SHC1 events in ERBB4 signaling
reactomeR-HSA-1251985Nuclear signaling by ERBB4
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1963640GRB2 events in ERBB2 signaling
reactomeR-HSA-1963642PI3K events in ERBB2 signaling
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6785631ERBB2 Regulates Cell Motility
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-8847993ERBB2 Activates PTK6 Signaling
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8863795Downregulation of ERBB2 signaling
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
piderbb_network_pathwayErbB receptor signaling network
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
wikipathwaysWP673ErbB Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD898EGFR mAb inhibitor2
iGMDRD792Cetuximab1
iGMDRD967Panitumumab1
iGMDRD816anti-EGFR mAbs2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EREG

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