ERO1A
Summary:
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
endoplasmic reticulum oxidoreductase 1 alpha | MIM:615435 | Ensembl:ENSG00000197930 | HGNC:HGNC:13280 | PA27862 | 14q22.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in ERO1A
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0003756 | protein disulfide isomerase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IBA | GO:0015035 | protein disulfide oxidoreductase activity |
MF | TAS | GO:0015036 | disulfide oxidoreductase activity |
MF | IDA | GO:0016491 | oxidoreductase activity |
MF | IEA | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor |
CC | IDA | GO:0005783 | endoplasmic reticulum |
CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
CC | IBA | GO:0005789 | endoplasmic reticulum membrane |
CC | HDA | GO:0016020 | membrane |
CC | IEA | GO:0030425 | dendrite |
CC | TAS | GO:0043231 | intracellular membrane-bounded organelle |
BP | TAS | GO:0006457 | protein folding |
BP | TAS | GO:0006464 | cellular protein modification process |
BP | TAS | GO:0009266 | response to temperature stimulus |
BP | IEA | GO:0010260 | animal organ senescence |
BP | IEA | GO:0019471 | 4-hydroxyproline metabolic process |
BP | IEA | GO:0022417 | protein maturation by protein folding |
BP | IEA | GO:0030198 | extracellular matrix organization |
BP | IEA | GO:0030968 | endoplasmic reticulum unfolded protein response |
BP | TAS | GO:0034599 | cellular response to oxidative stress |
BP | IBA | GO:0034975 | protein folding in endoplasmic reticulum |
BP | ISS | GO:0034976 | response to endoplasmic reticulum stress |
BP | IEA | GO:0045454 | cell redox homeostasis |
BP | IEA | GO:0050873 | brown fat cell differentiation |
BP | IDA | GO:0051085 | chaperone cofactor-dependent protein refolding |
BP | ISS | GO:0051209 | release of sequestered calcium ion into cytosol |
BP | IEA | GO:0055114 | oxidation-reduction process |
BP | ISS | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
BP | IEA | GO:0071456 | cellular response to hypoxia |
Gene expression in normal tissue: ERO1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ERO1A
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
kegg | hsa05110 | Vibrio cholerae infection - Homo sapiens (human) |
reactome | R-HSA-2262752 | Cellular responses to stress |
reactome | R-HSA-264876 | Insulin processing |
reactome | R-HSA-2980736 | Peptide hormone metabolism |
reactome | R-HSA-3299685 | Detoxification of Reactive Oxygen Species |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-8953897 | Cellular responses to external stimuli |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in ERO1A