EXOC7


Summary: The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
exocyst complex component 7MIM:608163Ensembl:ENSG00000182473HGNC:HGNC:23214PA13498842017q25.1

GO terms in EXOC7


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0000145exocyst
CCIDAGO:0005815microtubule organizing center
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCHDAGO:0016020membrane
CCIEAGO:0032584growth cone membrane
CCIDAGO:0034451centriolar satellite
CCIEAGO:0090543Flemming body
BPIEAGO:0006887exocytosis
BPIEAGO:0015031protein transport
BPTASGO:0016241regulation of macroautophagy
BPIMPGO:2000535regulation of entry of bacterium into host cell
MFIPIGO:0005515protein binding

Gene expression in normal tissue: EXOC7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EXOC7


DatabasePathway IDPathway Des.
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
pidarf6_traffickingpathwayArf6 trafficking events
pidcdc42_pathwayCDC42 signaling events
pidinsulin_pathwayInsulin Pathway
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
reactomeR-HSA-1445148Translocation of SLC2A4 (GLUT4) to the plasma membrane
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-264876Insulin processing
reactomeR-HSA-2980736Peptide hormone metabolism
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5617833Cilium Assembly
reactomeR-HSA-5620916VxPx cargo-targeting to cilium
reactomeR-HSA-5620920Cargo trafficking to the periciliary membrane
reactomeR-HSA-5653656Vesicle-mediated transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD284Palbociclib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EXOC7

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