EXOC7
Summary: The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| exocyst complex component 7 | MIM:608163 | Ensembl:ENSG00000182473 | HGNC:HGNC:23214 | PA134988420 | 17q25.1 |
GO terms in EXOC7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000145 | exocyst |
| CC | IDA | GO:0005815 | microtubule organizing center |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0032584 | growth cone membrane |
| CC | IDA | GO:0034451 | centriolar satellite |
| CC | IEA | GO:0090543 | Flemming body |
| BP | IEA | GO:0006887 | exocytosis |
| BP | IEA | GO:0015031 | protein transport |
| BP | TAS | GO:0016241 | regulation of macroautophagy |
| BP | IMP | GO:2000535 | regulation of entry of bacterium into host cell |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: EXOC7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EXOC7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | insulin_pathway | Insulin Pathway |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-264876 | Insulin processing |
| reactome | R-HSA-2980736 | Peptide hormone metabolism |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620916 | VxPx cargo-targeting to cilium |
| reactome | R-HSA-5620920 | Cargo trafficking to the periciliary membrane |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EXOC7
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