Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein. [provided by RefSeq, Jul 2008].

F-box and leucine rich repeat protein 8MIM:609077Ensembl:ENSG00000135722HGNC:HGNC:17875PA2802816q22.1

GO terms in FBXL8

Term TypeEvidence TypeGO Term IDGO Des.
MFEXPGO:0004842ubiquitin-protein transferase activity
MFTASGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFIBAGO:0061630ubiquitin protein ligase activity
BPTASGO:0000209protein polyubiquitination
BPIBAGO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
BPTASGO:0043687post-translational protein modification
CCIBAGO:0019005SCF ubiquitin ligase complex

Gene expression in normal tissue: FBXL8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FBXL8

DatabasePathway IDPathway Des.
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FBXL8