FNDC5


Summary: This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
fibronectin type III domain containing 5MIM:611906Ensembl:ENSG00000160097HGNC:HGNC:20240PA1349246071p35.1

GO terms in FNDC5


Term TypeEvidence TypeGO Term IDGO Des.
MFNDGO:0003674molecular_function
MFIEAGO:0005179hormone activity
CCISSGO:0005576extracellular region
CCIEAGO:0005778peroxisomal membrane
CCIBAGO:0005783endoplasmic reticulum
CCISSGO:0005783endoplasmic reticulum
CCIBAGO:0005886plasma membrane
CCISSGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
BPNDGO:0008150biological_process
BPIEAGO:0010469regulation of signaling receptor activity
BPISSGO:0014850response to muscle activity
BPIBAGO:0090336positive regulation of brown fat cell differentiation
BPISSGO:0090336positive regulation of brown fat cell differentiation

Gene expression in normal tissue: FNDC5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FNDC5


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012
iGMDRD284Palbociclib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FNDC5

​​​​