FPGT
Summary: L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene. [provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| fucose-1-phosphate guanylyltransferase | MIM:603609 | Ensembl:ENSG00000254685 | HGNC:HGNC:3825 | PA28243 | 1p31.1 |
GO terms in FPGT
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003824 | catalytic activity |
| MF | IEA | GO:0005525 | GTP binding |
| MF | TAS | GO:0047341 | fucose-1-phosphate guanylyltransferase activity |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0006004 | fucose metabolic process |
Gene expression in normal tissue: FPGT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FPGT
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PWY-6 | GDP-L-fucose biosynthesis II (from L-fucose) |
| kegg | hsa00051 | Fructose and mannose metabolism - Homo sapiens (human) |
| kegg | hsa00520 | Amino sugar and nucleotide sugar metabolism - Homo sapiens (human) |
| smpdb | SMP00064 | Fructose and Mannose Degradation |
| smpdb | SMP00561 | Fructosuria |
| smpdb | SMP00725 | Fructose intolerance, hereditary |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6787639 | GDP-fucose biosynthesis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FPGT
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