Summary: L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene. [provided by RefSeq, Dec 2010].

fucose-1-phosphate guanylyltransferaseMIM:603609Ensembl:ENSG00000254685HGNC:HGNC:3825PA282431p31.1

GO terms in FPGT

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003824catalytic activity
MFIEAGO:0005525GTP binding
MFTASGO:0047341fucose-1-phosphate guanylyltransferase activity
BPTASGO:0006004fucose metabolic process

Gene expression in normal tissue: FPGT

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FPGT

DatabasePathway IDPathway Des.
humancycPWY-6GDP-L-fucose biosynthesis II (from L-fucose)
kegghsa00051Fructose and mannose metabolism - Homo sapiens (human)
kegghsa00520Amino sugar and nucleotide sugar metabolism - Homo sapiens (human)
smpdbSMP00064Fructose and Mannose Degradation
smpdbSMP00725Fructose intolerance, hereditary
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-446219Synthesis of substrates in N-glycan biosythesis
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6787639GDP-fucose biosynthesis

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FPGT