GABRE
Summary: The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| gamma-aminobutyric acid type A receptor epsilon subunit | MIM:300093 | Ensembl:ENSG00000102287 | HGNC:HGNC:4085 | PA28499 | Xq28 |
GO terms in GABRE
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | IBA | GO:0032590 | dendrite membrane |
| CC | IEA | GO:0034707 | chloride channel complex |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0045202 | synapse |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| CC | IBA | GO:0098794 | postsynapse |
| CC | IBA | GO:1902711 | GABA-A receptor complex |
| CC | IDA | GO:1902711 | GABA-A receptor complex |
| BP | IBA | GO:0007165 | signal transduction |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IBA | GO:0007214 | gamma-aminobutyric acid signaling pathway |
| BP | IBA | GO:0007268 | chemical synaptic transmission |
| BP | IBA | GO:0034220 | ion transmembrane transport |
| BP | IBA | GO:0042391 | regulation of membrane potential |
| BP | IBA | GO:0050877 | nervous system process |
| BP | IBA | GO:0051932 | synaptic transmission, GABAergic |
| BP | IBA | GO:0060078 | regulation of postsynaptic membrane potential |
| BP | IBA | GO:1902476 | chloride transmembrane transport |
| BP | IEA | GO:1902476 | chloride transmembrane transport |
| BP | IDA | GO:2001226 | negative regulation of chloride transport |
| MF | IBA | GO:0004890 | GABA-A receptor activity |
| MF | IEA | GO:0004890 | GABA-A receptor activity |
| MF | IBA | GO:0005230 | extracellular ligand-gated ion channel activity |
| MF | IBA | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity |
| MF | IBA | GO:0005254 | chloride channel activity |
| MF | IBA | GO:0008503 | benzodiazepine receptor activity |
| MF | IBA | GO:0022851 | GABA-gated chloride ion channel activity |
| MF | IDA | GO:0022851 | GABA-gated chloride ion channel activity |
| MF | IBA | GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
Gene expression in normal tissue: GABRE
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GABRE
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4159 | GABA receptor Signaling |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04727 | GABAergic synapse - Homo sapiens (human) |
| kegg | hsa05032 | Morphine addiction - Homo sapiens (human) |
| kegg | hsa05033 | Nicotine addiction - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GABRE
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