Summary: This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. [provided by RefSeq, Jul 2008].

polypeptide N-acetylgalactosaminyltransferase 8MIM:606250Ensembl:ENSG00000130035HGNC:HGNC:4130PA2854312p13.32

GO terms in GALNT8

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0000139Golgi membrane
CCIBAGO:0005794Golgi apparatus
CCIEAGO:0016021integral component of membrane
CCIDAGO:0043231intracellular membrane-bounded organelle
BPTASGO:0016266O-glycan processing
MFTASGO:0004653polypeptide N-acetylgalactosaminyltransferase activity
MFIEAGO:0030246carbohydrate binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: GALNT8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GALNT8

DatabasePathway IDPathway Des.
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5173105O-linked glycosylation
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-913709O-linked glycosylation of mucins
humancycPWY-7433mucin core 1 and core 2 O-glycosylation
kegghsa00512Mucin type O-glycan biosynthesis - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GALNT8