GALNT8
Summary: This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| polypeptide N-acetylgalactosaminyltransferase 8 | MIM:606250 | Ensembl:ENSG00000130035 | HGNC:HGNC:4130 | PA28543 | 12p13.32 |
GO terms in GALNT8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IBA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | TAS | GO:0016266 | O-glycan processing |
| MF | TAS | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity |
| MF | IEA | GO:0030246 | carbohydrate binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: GALNT8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GALNT8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5173105 | O-linked glycosylation |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-913709 | O-linked glycosylation of mucins |
| humancyc | PWY-7433 | mucin core 1 and core 2 O-glycosylation |
| kegg | hsa00512 | Mucin type O-glycan biosynthesis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GALNT8
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