GAST


Summary: Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
gastrinMIM:137250Ensembl:ENSG00000184502HGNC:HGNC:4164PA2857717q21.2

GO terms in GAST


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005179hormone activity
MFIPIGO:0005515protein binding
BPNASGO:0007165signal transduction
BPIBAGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0010469regulation of signaling receptor activity
BPIBAGO:0032094response to food
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space

Gene expression in normal tissue: GAST

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GAST


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-881907Gastrin-CREB signalling pathway via PKC and MAPK
netpathPathway_GastrinGastrin
kegghsa04971Gastric acid secretion - Homo sapiens (human)
smpdbSMP00225Esomeprazole Action Pathway
smpdbSMP00226Omeprazole Action Pathway
smpdbSMP00227Lansoprazole Action Pathway
smpdbSMP00228Pantoprazole Action Pathway
smpdbSMP00229Rabeprazole Action Pathway
smpdbSMP00230Ranitidine Action Pathway
smpdbSMP00231Famotidine Action Pathway
smpdbSMP00232Cimetidine Action Pathway
smpdbSMP00233Nizatidine Action Pathway
smpdbSMP00246Pirenzepine Action Pathway
smpdbSMP00589Gastric Acid Production
smpdbSMP00734Roxatidine acetate Action Pathway
smpdbSMP00735Metiamide Action Pathway
smpdbSMP00736Betazole Action Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD133Lapatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GAST

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