HGS
Summary: The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| hepatocyte growth factor-regulated tyrosine kinase substrate | MIM:604375 | Ensembl:ENSG00000185359 | HGNC:HGNC:4897 | PA29271 | 17q25.3 |
GO terms in HGS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IPI | GO:0044389 | ubiquitin-like protein ligase binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IDA | GO:0005764 | lysosome |
| CC | IDA | GO:0005768 | endosome |
| CC | IDA | GO:0005769 | early endosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0031901 | early endosome membrane |
| CC | IEA | GO:0032585 | multivesicular body membrane |
| CC | IDA | GO:0033565 | ESCRT-0 complex |
| CC | TAS | GO:0033565 | ESCRT-0 complex |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IMP | GO:0006622 | protein targeting to lysosome |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IMP | GO:0010324 | membrane invagination |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IMP | GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway |
| BP | NAS | GO:0016197 | endosomal transport |
| BP | TAS | GO:0016197 | endosomal transport |
| BP | TAS | GO:0016236 | macroautophagy |
| BP | IMP | GO:0016525 | negative regulation of angiogenesis |
| BP | IMP | GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway |
| BP | TAS | GO:0036258 | multivesicular body assembly |
| BP | TAS | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0042176 | regulation of protein catabolic process |
| BP | IMP | GO:0043405 | regulation of MAP kinase activity |
| BP | IDA | GO:0046426 | negative regulation of JAK-STAT cascade |
| BP | TAS | GO:0061024 | membrane organization |
| BP | IMP | GO:0072657 | protein localization to membrane |
| BP | IMP | GO:1903543 | positive regulation of exosomal secretion |
Gene expression in normal tissue: HGS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HGS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-182971 | EGFR downregulation |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-199992 | trans-Golgi Network Vesicle Budding |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-421837 | Clathrin derived vesicle budding |
| reactome | R-HSA-432720 | Lysosome Vesicle Biogenesis |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-6807004 | Negative regulation of MET activity |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| reactome | R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell |
| reactome | R-HSA-8876384 | Listeria monocytogenes entry into host cells |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HGS
CLASSFICATION
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