HIF3A


Summary: The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
hypoxia inducible factor 3 subunit alphaMIM:609976Ensembl:ENSG00000124440HGNC:HGNC:15825PA2928519q13.32

GO terms in HIF3A


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003677DNA binding
MFIEAGO:0046983protein dimerization activity
CCIBAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005739mitochondrion
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCIEAGO:0016607nuclear speck
BPIEAGO:0001525angiogenesis
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006366transcription by RNA polymerase II
BPIEAGO:0006915apoptotic process
BPTASGO:0043687post-translational protein modification
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPTASGO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia

Gene expression in normal tissue: HIF3A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HIF3A


DatabasePathway IDPathway Des.
pidhif1apathwayHypoxic and oxygen homeostasis regulation of HIF-1-alpha
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
reactomeR-HSA-1234158Regulation of gene expression by Hypoxia-inducible Factor
reactomeR-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygen
reactomeR-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-2262749Cellular response to hypoxia
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-452723Transcriptional regulation of pluripotent stem cells
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8951664Neddylation
reactomeR-HSA-8953897Cellular responses to external stimuli

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD284Palbociclib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HIF3A

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