HIVEP1


Summary: This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. [provided by RefSeq, Oct 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
human immunodeficiency virus type I enhancer binding protein 1MIM:194540Ensembl:ENSG00000095951HGNC:HGNC:4920PA292976p24.1

GO terms in HIVEP1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001206transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
MFTASGO:0003677DNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005739mitochondrion
CCIDAGO:0016604nuclear body

Gene expression in normal tissue: HIVEP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HIVEP1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD134Sorafenib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HIVEP1

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