Summary: HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008].

major histocompatibility complex, class II, DR alphaMIM:142860Ensembl:ENSG00000204287HGNC:HGNC:4947PA350716p21.32

GO terms in HLA-DRA

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0000139Golgi membrane
CCIDAGO:0005765lysosomal membrane
CCTASGO:0005765lysosomal membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCNASGO:0005887integral component of plasma membrane
CCIDAGO:0009986cell surface
CCTASGO:0012507ER to Golgi transport vesicle membrane
CCTASGO:0030658transport vesicle membrane
CCTASGO:0030666endocytic vesicle membrane
CCTASGO:0030669clathrin-coated endocytic vesicle membrane
CCIDAGO:0031902late endosome membrane
CCTASGO:0032588trans-Golgi network membrane
CCIDAGO:0042613MHC class II protein complex
CCIMPGO:0042613MHC class II protein complex
CCHDAGO:0070062extracellular exosome
CCTASGO:0071556integral component of lumenal side of endoplasmic reticulum membrane
BPIDAGO:0002503peptide antigen assembly with MHC class II protein complex
BPIDAGO:0002504antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
BPIDAGO:0002506polysaccharide assembly with MHC class II protein complex
BPNASGO:0006955immune response
BPIEAGO:0016032viral process
BPTASGO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II
BPTASGO:0050852T cell receptor signaling pathway
BPTASGO:0060333interferon-gamma-mediated signaling pathway
MFIPIGO:0005515protein binding
MFHDAGO:0023026MHC class II protein complex binding
MFNASGO:0032395MHC class II receptor activity
MFIDAGO:0042605peptide antigen binding

Gene expression in normal tissue: HLA-DRA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HLA-DRA

DatabasePathway IDPathway Des.
biocartacskpathwayactivation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
biocartactla4pathwaythe co-stimulatory signal during t-cell activation
biocartail4pathwayil 4 signaling pathway
biocartamef2dpathwayrole of mef2d in t-cell apoptosis
biocartamhcpathwayantigen processing and presentation
biocartatcrapathwaylck and fyn tyrosine kinases in initiation of tcr activation
biocartatcrpathwayt cell receptor signaling pathway
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-202427Phosphorylation of CD3 and TCR zeta chains
reactomeR-HSA-202430Translocation of ZAP-70 to Immunological synapse
reactomeR-HSA-202433Generation of second messenger molecules
reactomeR-HSA-2132295MHC class II antigen presentation
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389948PD-1 signaling
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-913531Interferon Signaling
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP4141PI3K-AKT-mTOR - VitD3 Signalling
wikipathwaysWP530Cytokines and Inflammatory Response
kegghsa04145Phagosome - Homo sapiens (human)
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa04612Antigen processing and presentation - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04672Intestinal immune network for IgA production - Homo sapiens (human)
kegghsa04940Type I diabetes mellitus - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05150Staphylococcus aureus infection - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05310Asthma - Homo sapiens (human)
kegghsa05320Autoimmune thyroid disease - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
kegghsa05322Systemic lupus erythematosus - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
kegghsa05330Allograft rejection - Homo sapiens (human)
kegghsa05332Graft-versus-host disease - Homo sapiens (human)
kegghsa05416Viral myocarditis - Homo sapiens (human)
pidcxcr4_pathwayCXCR4-mediated signaling events
pidil12_2pathwayIL12-mediated signaling events
pidil12_stat4pathwayIL12 signaling mediated by STAT4
pidtcr_pathwayTCR signaling in naïve CD4+ T cells

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HLA-DRA