GO terms in HMGCS1


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005737cytoplasm
CCIBAGO:0005829cytosol
CCTASGO:0005829cytosol
BPIEAGO:0001889liver development
BPIBAGO:0006084acetyl-CoA metabolic process
BPNASGO:0006629lipid metabolic process
BPTASGO:0006695cholesterol biosynthetic process
BPIEAGO:0007420brain development
BPIEAGO:0008299isoprenoid biosynthetic process
BPIEAGO:0008584male gonad development
BPIEAGO:0009645response to low light intensity stimulus
BPIBAGO:0010142farnesyl diphosphate biosynthetic process, mevalonate pathway
BPIEAGO:0014074response to purine-containing compound
BPTASGO:0019216regulation of lipid metabolic process
BPIEAGO:0033197response to vitamin E
BPIEAGO:0042493response to drug
BPTASGO:0045540regulation of cholesterol biosynthetic process
BPIEAGO:0046690response to tellurium ion
BPIEAGO:0071372cellular response to follicle-stimulating hormone stimulus
BPIEAGO:0071397cellular response to cholesterol
BPIEAGO:0071404cellular response to low-density lipoprotein particle stimulus
MFIBAGO:0004421hydroxymethylglutaryl-CoA synthase activity
MFTASGO:0004421hydroxymethylglutaryl-CoA synthase activity
MFIEAGO:0008144drug binding
MFIEAGO:0016853isomerase activity
MFIDAGO:0042803protein homodimerization activity
MFIEAGO:0043177organic acid binding

Gene expression in normal tissue: HMGCS1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HMGCS1


DatabasePathway IDPathway Des.
humancycPWY-5910superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
humancycPWY-922mevalonate pathway
humancycPWY66-367ketogenesis
humancycPWY66-5superpathway of cholesterol biosynthesis
kegghsa00072Synthesis and degradation of ketone bodies - Homo sapiens (human)
kegghsa00280Valine, leucine and isoleucine degradation - Homo sapiens (human)
kegghsa00650Butanoate metabolism - Homo sapiens (human)
kegghsa00900Terpenoid backbone biosynthesis - Homo sapiens (human)
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)
reactomeR-HSA-191273Cholesterol biosynthesis
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-2426168Activation of gene expression by SREBF (SREBP)
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-8957322Metabolism of steroids
biocartas1ppathwaysrebp control of lipid synthesis
pharmgkbPA154423660Bisphosphonate Pathway, Pharmacodynamics
pidhnf3bpathwayFOXA2 and FOXA3 transcription factor networks
smpdbSMP00023Steroid Biosynthesis
smpdbSMP00079Ibandronate Action Pathway
smpdbSMP00082Simvastatin Action Pathway
smpdbSMP00089Pravastatin Action Pathway
smpdbSMP00092Rosuvastatin Action Pathway
smpdbSMP00095Alendronate Action Pathway
smpdbSMP00099Lovastatin Action Pathway
smpdbSMP00107Zoledronate Action Pathway
smpdbSMP00111Cerivastatin Action Pathway
smpdbSMP00112Risedronate Action Pathway
smpdbSMP00117Pamidronate Action Pathway
smpdbSMP00119Fluvastatin Action Pathway
smpdbSMP00131Atorvastatin Action Pathway
smpdbSMP00209Hypercholesterolemia
smpdbSMP00319Lysosomal Acid Lipase Deficiency (Wolman Disease)
smpdbSMP00386Desmosterolosis
smpdbSMP00387CHILD Syndrome
smpdbSMP00388Chondrodysplasia Punctata II, X Linked Dominant (CDPX2)
smpdbSMP00389Smith-Lemli-Opitz Syndrome (SLOS)
smpdbSMP00508Cholesteryl ester storage disease
smpdbSMP00509Hyper-IgD syndrome
smpdbSMP00510Mevalonic aciduria
smpdbSMP00511Wolman disease
wikipathwaysWP197Cholesterol Biosynthesis
wikipathwaysWP1982Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathwaysWP2011SREBF and miR33 in cholesterol and lipid homeostasis
wikipathwaysWP2706Activation of gene expression by SREBF (SREBP)
wikipathwaysWP2797Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
wikipathwaysWP3963Mevalonate pathway
wikipathwaysWP474Endochondral Ossification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD536PLX-47201

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HMGCS1

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