HMOX1
Summary: Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| heme oxygenase 1 | MIM:141250 | Ensembl:ENSG00000100292 | HGNC:HGNC:5013 | PA29341 | 22q12.3 |
GO terms in HMOX1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004392 | heme oxygenase (decyclizing) activity |
| MF | IDA | GO:0004392 | heme oxygenase (decyclizing) activity |
| MF | IMP | GO:0004392 | heme oxygenase (decyclizing) activity |
| MF | TAS | GO:0004392 | heme oxygenase (decyclizing) activity |
| MF | IEA | GO:0004630 | phospholipase D activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0019899 | enzyme binding |
| MF | IBA | GO:0020037 | heme binding |
| MF | IDA | GO:0020037 | heme binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | TAS | GO:0001525 | angiogenesis |
| BP | TAS | GO:0001935 | endothelial cell proliferation |
| BP | IMP | GO:0002246 | wound healing involved in inflammatory response |
| BP | TAS | GO:0002686 | negative regulation of leukocyte migration |
| BP | IBA | GO:0006788 | heme oxidation |
| BP | IDA | GO:0006788 | heme oxidation |
| BP | IMP | GO:0006879 | cellular iron ion homeostasis |
| BP | TAS | GO:0006879 | cellular iron ion homeostasis |
| BP | IBA | GO:0006979 | response to oxidative stress |
| BP | IMP | GO:0006979 | response to oxidative stress |
| BP | IEA | GO:0007264 | small GTPase mediated signal transduction |
| BP | IC | GO:0007588 | excretion |
| BP | IEA | GO:0008217 | regulation of blood pressure |
| BP | ISS | GO:0008219 | cell death |
| BP | IEA | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IEA | GO:0010656 | negative regulation of muscle cell apoptotic process |
| BP | TAS | GO:0014806 | smooth muscle hyperplasia |
| BP | IEA | GO:0016239 | positive regulation of macroautophagy |
| BP | IEA | GO:0016242 | negative regulation of macroautophagy |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0031670 | cellular response to nutrient |
| BP | IEA | GO:0032764 | negative regulation of mast cell cytokine production |
| BP | IMP | GO:0034101 | erythrocyte homeostasis |
| BP | TAS | GO:0034383 | low-density lipoprotein particle clearance |
| BP | IEA | GO:0034395 | regulation of transcription from RNA polymerase II promoter in response to iron |
| BP | IMP | GO:0034605 | cellular response to heat |
| BP | IDA | GO:0035094 | response to nicotine |
| BP | TAS | GO:0035556 | intracellular signal transduction |
| BP | IBA | GO:0042167 | heme catabolic process |
| BP | IDA | GO:0042167 | heme catabolic process |
| BP | TAS | GO:0042167 | heme catabolic process |
| BP | ISS | GO:0042542 | response to hydrogen peroxide |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | HMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043305 | negative regulation of mast cell degranulation |
| BP | IEA | GO:0043392 | negative regulation of DNA binding |
| BP | IEA | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | ISS | GO:0043619 | regulation of transcription from RNA polymerase II promoter in response to oxidative stress |
| BP | IEA | GO:0043627 | response to estrogen |
| BP | TAS | GO:0045080 | positive regulation of chemokine biosynthetic process |
| BP | TAS | GO:0045765 | regulation of angiogenesis |
| BP | IDA | GO:0045766 | positive regulation of angiogenesis |
| BP | IDA | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | IDA | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| BP | ISS | GO:0051090 | regulation of DNA-binding transcription factor activity |
| BP | IDA | GO:0051260 | protein homooligomerization |
| BP | IBA | GO:0055072 | iron ion homeostasis |
| BP | IDA | GO:0055072 | iron ion homeostasis |
| BP | IMP | GO:0055072 | iron ion homeostasis |
| BP | IEA | GO:0071243 | cellular response to arsenic-containing substance |
| BP | IEA | GO:0071276 | cellular response to cadmium ion |
| BP | IEP | GO:0071456 | cellular response to hypoxia |
| BP | IEA | GO:0072719 | cellular response to cisplatin |
| BP | IGI | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis |
| BP | IEA | GO:0097421 | liver regeneration |
| BP | IC | GO:0097755 | positive regulation of blood vessel diameter |
| BP | IMP | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IGI | GO:1903589 | positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| BP | IEA | GO:1904036 | negative regulation of epithelial cell apoptotic process |
| BP | IEA | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation |
| CC | TAS | GO:0005615 | extracellular space |
| CC | ISS | GO:0005634 | nucleus |
| CC | IEA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | ISS | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0005829 | cytosol |
| CC | IEA | GO:0005901 | caveola |
| CC | IBA | GO:0016020 | membrane |
| CC | TAS | GO:0016020 | membrane |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: HMOX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HMOX1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00860 | Porphyrin and chlorophyll metabolism - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04216 | Ferroptosis - Homo sapiens (human) |
| kegg | hsa04978 | Mineral absorption - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| pid | fra_pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| humancyc | PWY-5874 | heme degradation |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP3 | Transcriptional activation by NRF2 |
| wikipathways | WP3287 | Overview of nanoparticle effects |
| wikipathways | WP3612 | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| wikipathways | WP3624 | Lung fibrosis |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP408 | Oxidative Stress |
| smpdb | SMP00024 | Porphyrin Metabolism |
| smpdb | SMP00342 | Hereditary Coproporphyria (HCP) |
| smpdb | SMP00344 | Acute Intermittent Porphyria |
| smpdb | SMP00345 | Congenital Erythropoietic Porphyria (CEP) or Gunther Disease |
| smpdb | SMP00346 | Porphyria Variegata (PV) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-189445 | Metabolism of porphyrins |
| reactome | R-HSA-189483 | Heme degradation |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-917937 | Iron uptake and transport |
| biocarta | arenrf2pathway | oxidative stress induced gene expression via nrf2 |
| biocarta | il10pathway | il-10 anti-inflammatory signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD134 | Sorafenib | 1 |
| iGMDRD309 | 17AAG | 2 |
| iGMDRD241 | Sunitinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HMOX1
CLASSFICATION
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