HOXB2


Summary: This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
homeobox B2MIM:142967Ensembl:ENSG00000173917HGNC:HGNC:5113PA2938917q21.32

GO terms in HOXB2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0002011morphogenesis of an epithelial sheet
BPIEAGO:0006366transcription by RNA polymerase II
BPTASGO:0007275multicellular organism development
BPTASGO:0008015blood circulation
BPIEAGO:0009952anterior/posterior pattern specification
BPIEAGO:0009953dorsal/ventral pattern formation
BPIEAGO:0021569rhombomere 3 development
BPIEAGO:0021570rhombomere 4 development
BPIEAGO:0021612facial nerve structural organization
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048704embryonic skeletal system morphogenesis
BPIEAGO:0048857neural nucleus development
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCIDAGO:0016607nuclear speck
MFIBAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFICGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIDAGO:0043565sequence-specific DNA binding

Gene expression in normal tissue: HOXB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HOXB2


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesis
reactomeR-HSA-5619507Activation of HOX genes during differentiation
wikipathwaysWP3813Activation of anterior HOX genes in hindbrain development during early embryogenesis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD190Nilotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HOXB2

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