HSD17B12
Summary: This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| hydroxysteroid 17-beta dehydrogenase 12 | MIM:609574 | Ensembl:ENSG00000149084 | HGNC:HGNC:18646 | PA38618 | 11p11.2 |
GO terms in HSD17B12
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001968 | fibronectin binding |
| MF | IEA | GO:0004303 | estradiol 17-beta-dehydrogenase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005518 | collagen binding |
| MF | IEA | GO:0008201 | heparin binding |
| MF | EXP | GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity |
| MF | IBA | GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity |
| MF | IEA | GO:0102339 | 3-oxo-arachidoyl-CoA reductase activity |
| MF | IEA | GO:0102340 | 3-oxo-behenoyl-CoA reductase activity |
| MF | IEA | GO:0102341 | 3-oxo-lignoceroyl-CoA reductase activity |
| MF | IEA | GO:0102342 | 3-oxo-cerotoyl-CoA reductase activity |
| BP | IEA | GO:0006633 | fatty acid biosynthetic process |
| BP | IEA | GO:0006703 | estrogen biosynthetic process |
| BP | IEA | GO:0010811 | positive regulation of cell-substrate adhesion |
| BP | IEA | GO:0030198 | extracellular matrix organization |
| BP | TAS | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: HSD17B12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSD17B12
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| kegg | hsa00062 | Fatty acid elongation - Homo sapiens (human) |
| kegg | hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| kegg | hsa01040 | Biosynthesis of unsaturated fatty acids - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-193048 | Androgen biosynthesis |
| reactome | R-HSA-196071 | Metabolism of steroid hormones |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-75105 | Fatty acyl-CoA biosynthesis |
| reactome | R-HSA-75876 | Synthesis of very long-chain fatty acyl-CoAs |
| reactome | R-HSA-8957322 | Metabolism of steroids |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HSD17B12
CLASSFICATION
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