HSD17B12 Summary: This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011].
GO terms in HSD17B12 Term Type Evidence Type GO Term ID GO Des. MF IEA GO:0001968 fibronectin binding MF IEA GO:0004303 estradiol 17-beta-dehydrogenase activity MF IPI GO:0005515 protein binding MF IEA GO:0005518 collagen binding MF IEA GO:0008201 heparin binding MF EXP GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity MF IBA GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity MF IEA GO:0102339 3-oxo-arachidoyl-CoA reductase activity MF IEA GO:0102340 3-oxo-behenoyl-CoA reductase activity MF IEA GO:0102341 3-oxo-lignoceroyl-CoA reductase activity MF IEA GO:0102342 3-oxo-cerotoyl-CoA reductase activity BP IEA GO:0006633 fatty acid biosynthetic process BP IEA GO:0006703 estrogen biosynthetic process BP IEA GO:0010811 positive regulation of cell-substrate adhesion BP IEA GO:0030198 extracellular matrix organization BP TAS GO:0035338 long-chain fatty-acyl-CoA biosynthetic process BP IEA GO:0055114 oxidation-reduction process CC TAS GO:0005789 endoplasmic reticulum membrane CC IEA GO:0016021 integral component of membrane
Gene expression in normal tissue: HSD17B12
Select Project:
Transcriptome or Gene expression: PRJEB2445
Transcriptome or Gene expression: PRJEB4337
Transcriptome or Gene expression: PRJNA270632
Transcriptome or Gene expression: PRJNA280600
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Gene-model tissue-cancer distribution: Bubble Plot
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Gene-drug pathway distribution
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