HSPA5


Summary: The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
heat shock protein family A (Hsp70) member 5MIM:138120Ensembl:ENSG00000044574HGNC:HGNC:5238PA295049q33.3

GO terms in HSPA5


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006983ER overload response
BPIBAGO:0006986response to unfolded protein
BPIEAGO:0010976positive regulation of neuron projection development
BPIEAGO:0021589cerebellum structural organization
BPIEAGO:0021680cerebellar Purkinje cell layer development
BPHEPGO:0021762substantia nigra development
BPIEAGO:0030182neuron differentiation
BPIMPGO:0030335positive regulation of cell migration
BPIBAGO:0030433ubiquitin-dependent ERAD pathway
BPTASGO:0030433ubiquitin-dependent ERAD pathway
BPIEAGO:0030512negative regulation of transforming growth factor beta receptor signaling pathway
BPIBAGO:0030968endoplasmic reticulum unfolded protein response
BPTASGO:0030968endoplasmic reticulum unfolded protein response
BPIEAGO:0031398positive regulation of protein ubiquitination
BPIBAGO:0034605cellular response to heat
BPIBAGO:0034620cellular response to unfolded protein
BPTASGO:0034975protein folding in endoplasmic reticulum
BPIMPGO:0035437maintenance of protein localization in endoplasmic reticulum
BPIEAGO:0035690cellular response to drug
BPTASGO:0036498IRE1-mediated unfolded protein response
BPTASGO:0036499PERK-mediated unfolded protein response
BPTASGO:0036500ATF6-mediated unfolded protein response
BPIBAGO:0042026protein refolding
BPIDAGO:0042149cellular response to glucose starvation
BPIEAGO:0042220response to cocaine
BPIMPGO:0043066negative regulation of apoptotic process
BPTASGO:0043066negative regulation of apoptotic process
BPIBAGO:0051085chaperone cofactor-dependent protein refolding
BPIEAGO:0051402neuron apoptotic process
BPTASGO:0060904regulation of protein folding in endoplasmic reticulum
BPIEAGO:0071236cellular response to antibiotic
BPIEAGO:0071277cellular response to calcium ion
BPIEAGO:0071287cellular response to manganese ion
BPIEAGO:0071320cellular response to cAMP
BPIEAGO:0071353cellular response to interleukin-4
BPIEAGO:0071480cellular response to gamma radiation
BPISSGO:0090074negative regulation of protein homodimerization activity
BPTASGO:0090074negative regulation of protein homodimerization activity
BPIEAGO:0097501stress response to metal ion
BPIEAGO:1901998toxin transport
BPTASGO:1903891regulation of ATF6-mediated unfolded protein response
BPTASGO:1903894regulation of IRE1-mediated unfolded protein response
BPISSGO:1903895negative regulation of IRE1-mediated unfolded protein response
BPTASGO:1903897regulation of PERK-mediated unfolded protein response
BPIEAGO:1904313response to methamphetamine hydrochloride
BPIEAGO:1990090cellular response to nerve growth factor stimulus
BPTASGO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
CCHDAGO:0005634nucleus
CCIBAGO:0005634nucleus
CCIMPGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIEAGO:0005739mitochondrion
CCIDAGO:0005783endoplasmic reticulum
CCIMPGO:0005783endoplasmic reticulum
CCTASGO:0005783endoplasmic reticulum
CCIBAGO:0005788endoplasmic reticulum lumen
CCTASGO:0005788endoplasmic reticulum lumen
CCTASGO:0005789endoplasmic reticulum membrane
CCIEAGO:0005790smooth endoplasmic reticulum
CCIDAGO:0005793endoplasmic reticulum-Golgi intermediate compartment
CCIEAGO:0005886plasma membrane
CCHDAGO:0005925focal adhesion
CCIDAGO:0008180COP9 signalosome
CCIEAGO:0009986cell surface
CCHDAGO:0016020membrane
CCIBAGO:0016020membrane
CCIDAGO:0030176integral component of endoplasmic reticulum membrane
CCIDAGO:0030496midbody
CCIDAGO:0032991protein-containing complex
CCIBAGO:0034663endoplasmic reticulum chaperone complex
CCIDAGO:0034663endoplasmic reticulum chaperone complex
CCIEAGO:0042470melanosome
CCIEAGO:0043209myelin sheath
CCHDAGO:0070062extracellular exosome
MFTASGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIBAGO:0005524ATP binding
MFIEAGO:0005524ATP binding
MFIBAGO:0016887ATPase activity
MFIDAGO:0016887ATPase activity
MFISSGO:0016887ATPase activity
MFIPIGO:0019899enzyme binding
MFIPIGO:0019904protein domain specific binding
MFIBAGO:0031072heat shock protein binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIBAGO:0042623ATPase activity, coupled
MFIEAGO:0043022ribosome binding
MFIBAGO:0044183protein binding involved in protein folding
MFHDAGO:0045296cadherin binding
MFIBAGO:0051082unfolded protein binding
MFTASGO:0051082unfolded protein binding
MFTASGO:0051087chaperone binding
MFIBAGO:0051787misfolded protein binding
MFIDAGO:0051787misfolded protein binding

Gene expression in normal tissue: HSPA5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HSPA5


DatabasePathway IDPathway Des.
kegghsa03060Protein export - Homo sapiens (human)
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegghsa04612Antigen processing and presentation - Homo sapiens (human)
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa05020Prion diseases - Homo sapiens (human)
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_TSHTSH
wikipathwaysWP2359Parkin-Ubiquitin Proteasomal System pathway
wikipathwaysWP2655ATF6 (ATF6-alpha) activates chaperone genes
wikipathwaysWP2864Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathwaysWP3613Photodynamic therapy-induced unfolded protein response
wikipathwaysWP3995Prion disease pathway
smpdbSMP00074Retinol Metabolism
smpdbSMP00086Ibuprofen Action Pathway
smpdbSMP00327Phenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00336Vitamin A Deficiency
smpdbSMP00406Morphine Action Pathway
smpdbSMP00433Irinotecan Action Pathway
smpdbSMP00442Etoposide Action Pathway
smpdbSMP00590Ibuprofen Metabolism Pathway
smpdbSMP00600Irinotecan Metabolism Pathway
smpdbSMP00601Etoposide Metabolism Pathway
smpdbSMP00622Morphine Metabolism Pathway
smpdbSMP00640Acetaminophen Metabolism Pathway
smpdbSMP00648Sorafenib Metabolism Pathway
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-3371453Regulation of HSF1-mediated heat shock response
reactomeR-HSA-3371556Cellular response to heat stress
reactomeR-HSA-381033ATF6 (ATF6-alpha) activates chaperones
reactomeR-HSA-381042PERK regulates gene expression
reactomeR-HSA-381070IRE1alpha activates chaperones
reactomeR-HSA-381119Unfolded Protein Response (UPR)
reactomeR-HSA-381183ATF6 (ATF6-alpha) activates chaperone genes
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
reactomeR-HSA-983170Antigen Presentation: Folding, assembly and peptide loading of class I MHC
reactomeR-HSA-983170Antigen Presentation: Folding, assembly and peptide loading of class I MHC
biocartaprionpathwayprion pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD21Fluorouracil1
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HSPA5

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