HSPB7


Summary: This gene encodes a small heat shock family B member that can heterodimerize with similar heat shock proteins. Defects in this gene are associated with advanced heart failure. In addition, the encoded protein may be a tumor suppressor in the p53 pathway, with defects in this gene being associated with renal cell carcinoma. [provided by RefSeq, Mar 2017].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in HSPB7


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF TAS GO:0008022 protein C-terminus binding
MF IEA GO:0031005 filamin binding
BP TAS GO:0006986 response to unfolded protein
BP IEA GO:0007507 heart development
BP TAS GO:0008016 regulation of heart contraction
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Gene expression in normal tissue: HSPB7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HSPB7


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Database
Pathway ID
Pathway Des.
wikipathways WP2895 Differentiation of white and brown adipocyte
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD456 Crizotinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HSPB7

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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