IFNLR1


Summary: The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
interferon lambda receptor 1MIM:607404Ensembl:ENSG00000185436HGNC:HGNC:18584PA1349848801p36.11

GO terms in IFNLR1


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004896cytokine receptor activity
MFNASGO:0004896cytokine receptor activity
MFIPIGO:0005515protein binding
BPISSGO:0002385mucosal immune response
BPNASGO:0008285negative regulation of cell proliferation
BPIBAGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPISSGO:0034342response to type III interferon
BPIDAGO:0050691regulation of defense response to virus by host
BPISSGO:0051607defense response to virus
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0016021integral component of membrane
CCNASGO:0016021integral component of membrane
CCIDAGO:0032002interleukin-28 receptor complex

Gene expression in normal tissue: IFNLR1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IFNLR1


DatabasePathway IDPathway Des.
wikipathwaysWP2113Type III interferon signaling
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449836Other interleukin signaling
reactomeR-HSA-8854691Interleukin-20 family signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD190Nilotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IFNLR1

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