IFNLR1
Summary: The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interferon lambda receptor 1 | MIM:607404 | Ensembl:ENSG00000185436 | HGNC:HGNC:18584 | PA134984880 | 1p36.11 |
GO terms in IFNLR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004896 | cytokine receptor activity |
| MF | NAS | GO:0004896 | cytokine receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| BP | ISS | GO:0002385 | mucosal immune response |
| BP | NAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IBA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | ISS | GO:0034342 | response to type III interferon |
| BP | IDA | GO:0050691 | regulation of defense response to virus by host |
| BP | ISS | GO:0051607 | defense response to virus |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0032002 | interleukin-28 receptor complex |
Gene expression in normal tissue: IFNLR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IFNLR1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2113 | Type III interferon signaling |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449836 | Other interleukin signaling |
| reactome | R-HSA-8854691 | Interleukin-20 family signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IFNLR1
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.