IGF2
Summary: This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| insulin like growth factor 2 | MIM:147470 | Ensembl:ENSG00000167244 | HGNC:HGNC:5466 | PA29699 | 11p15.5 |
GO terms in IGF2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0001501 | skeletal system development |
| BP | IEA | GO:0001649 | osteoblast differentiation |
| BP | ISS | GO:0001701 | in utero embryonic development |
| BP | ISS | GO:0001892 | embryonic placenta development |
| BP | ISS | GO:0001934 | positive regulation of protein phosphorylation |
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | IEA | GO:0006006 | glucose metabolic process |
| BP | TAS | GO:0006349 | regulation of gene expression by genetic imprinting |
| BP | NAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IC | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | TAS | GO:0008286 | insulin receptor signaling pathway |
| BP | IEA | GO:0009887 | animal organ morphogenesis |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0031017 | exocrine pancreas development |
| BP | ISS | GO:0031056 | regulation of histone modification |
| BP | ISS | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase |
| BP | IEA | GO:0040018 | positive regulation of multicellular organism growth |
| BP | IDA | GO:0042104 | positive regulation of activated T cell proliferation |
| BP | ISS | GO:0043085 | positive regulation of catalytic activity |
| BP | IDA | GO:0043410 | positive regulation of MAPK cascade |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | ISS | GO:0045725 | positive regulation of glycogen biosynthetic process |
| BP | IDA | GO:0045840 | positive regulation of mitotic nuclear division |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0046628 | positive regulation of insulin receptor signaling pathway |
| BP | ISS | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0051146 | striated muscle cell differentiation |
| BP | ISS | GO:0051147 | regulation of muscle cell differentiation |
| BP | IEA | GO:0051781 | positive regulation of cell division |
| BP | IDA | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | ISS | GO:0060669 | embryonic placenta morphogenesis |
| BP | IEA | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| BP | ISS | GO:2000467 | positive regulation of glycogen (starch) synthase activity |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005615 | extracellular space |
| CC | TAS | GO:0031093 | platelet alpha granule lumen |
| MF | IPI | GO:0005158 | insulin receptor binding |
| MF | IMP | GO:0005159 | insulin-like growth factor receptor binding |
| MF | IDA | GO:0005178 | integrin binding |
| MF | IEA | GO:0005179 | hormone activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008083 | growth factor activity |
| MF | ISS | GO:0043539 | protein serine/threonine kinase activator activity |
| MF | ISS | GO:0048018 | receptor ligand activity |
Gene expression in normal tissue: IGF2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IGF2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-2428933 | SHC-related events triggered by IGF1R |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP474 | Endochondral Ossification |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD462 | OSI-906 (Linsitinib) | 2 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD816 | anti-EGFR mAbs | 1 |
| iGMDRD898 | EGFR mAb inhibitor | 1 |
| iGMDRD800 | Cabazitaxel | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IGF2
CLASSFICATION
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