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IGF2BP2

Summary: This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
insulin like growth factor 2 mRNA binding protein 2	MIM:608289	Ensembl:ENSG00000073792	HGNC:HGNC:28867	PA128394577	3q27.2

GO terms in IGF2BP2

Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0009653	anatomical structure morphogenesis
BP	ISS	GO:0017148	negative regulation of translation
BP	IC	GO:0042035	regulation of cytokine biosynthetic process
BP	TAS	GO:0043488	regulation of mRNA stability
BP	IEA	GO:0051028	mRNA transport
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005856	cytoskeleton
MF	HDA	GO:0003723	RNA binding
MF	IDA	GO:0003730	mRNA 3'-UTR binding
MF	IPI	GO:0005515	protein binding
MF	ISS	GO:0045182	translation regulator activity
MF	IDA	GO:0048027	mRNA 5'-UTR binding

Gene expression in normal tissue: IGF2BP2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IGF2BP2

Database	Pathway ID	Pathway Des.
reactome	R-HSA-428359	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
reactome	R-HSA-8953854	Metabolism of RNA

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2
iGMDRD399	Selumetinib	4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IGF2BP2

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