IGF2BP2


Summary: This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
insulin like growth factor 2 mRNA binding protein 2MIM:608289Ensembl:ENSG00000073792HGNC:HGNC:28867PA1283945773q27.2

GO terms in IGF2BP2


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0009653anatomical structure morphogenesis
BPISSGO:0017148negative regulation of translation
BPICGO:0042035regulation of cytokine biosynthetic process
BPTASGO:0043488regulation of mRNA stability
BPIEAGO:0051028mRNA transport
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005856cytoskeleton
MFHDAGO:0003723RNA binding
MFIDAGO:0003730mRNA 3'-UTR binding
MFIPIGO:0005515protein binding
MFISSGO:0045182translation regulator activity
MFIDAGO:0048027mRNA 5'-UTR binding

Gene expression in normal tissue: IGF2BP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IGF2BP2


DatabasePathway IDPathway Des.
reactomeR-HSA-428359Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012
iGMDRD399Selumetinib4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IGF2BP2

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