IGFALS
Summary: The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| insulin like growth factor binding protein acid labile subunit | MIM:601489 | Ensembl:ENSG00000099769 | HGNC:HGNC:5468 | PA29702 | 16p13.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in IGFALS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005520 | insulin-like growth factor binding |
| MF | TAS | GO:0005520 | insulin-like growth factor binding |
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005615 | extracellular space |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0042567 | insulin-like growth factor ternary complex |
| CC | IDA | GO:0042567 | insulin-like growth factor ternary complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
Gene expression in normal tissue: IGFALS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IGFALS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IGFALS
CLASSFICATION
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