IGFBP7


Summary: This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
insulin like growth factor binding protein 7MIM:602867Ensembl:ENSG00000163453HGNC:HGNC:5476PA297094q12

Gene Categories:

DRUGGABLE GENOME

GO terms in IGFBP7


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIEAGO:0005520insulin-like growth factor binding
CCHDAGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCHDAGO:0005615extracellular space
CCTASGO:0005788endoplasmic reticulum lumen
CCHDAGO:0062023collagen-containing extracellular matrix
CCHDAGO:0062023collagen-containing extracellular matrix
CCHDAGO:0070062extracellular exosome
BPIEAGO:0001558regulation of cell growth
BPIDAGO:0007155cell adhesion
BPIEAGO:0007566embryo implantation
BPTASGO:0008285negative regulation of cell proliferation
BPIEAGO:0009408response to heat
BPIEAGO:0032526response to retinoic acid
BPIEAGO:0032870cellular response to hormone stimulus
BPTASGO:0043687post-translational protein modification
BPTASGO:0044267cellular protein metabolic process
BPIEAGO:0050810regulation of steroid biosynthetic process
BPIEAGO:0051414response to cortisol

Gene expression in normal tissue: IGFBP7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IGFBP7


DatabasePathway IDPathway Des.
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-8957275Post-translational protein phosphorylation
wikipathwaysWP3391Senescence-Associated Secretory Phenotype (SASP)
wikipathwaysWP3670Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP615Senescence and Autophagy in Cancer

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD434BMS-5369241

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IGFBP7

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