INSC
Summary: In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| INSC, spindle orientation adaptor protein | MIM:610668 | Ensembl:ENSG00000188487 | HGNC:HGNC:33116 | PA162392191 | 11p15.2 |
GO terms in INSC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IPI | GO:0030674 | protein binding, bridging |
| CC | IMP | GO:0005886 | plasma membrane |
| CC | IMP | GO:0005938 | cell cortex |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IMP | GO:0032991 | protein-containing complex |
| BP | IEA | GO:0007399 | nervous system development |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0031647 | regulation of protein stability |
Gene expression in normal tissue: INSC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in INSC
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in INSC
CLASSFICATION
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