INSC


Summary: In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
INSC, spindle orientation adaptor proteinMIM:610668Ensembl:ENSG00000188487HGNC:HGNC:33116PA16239219111p15.2

GO terms in INSC


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIPIGO:0019904protein domain specific binding
MFIPIGO:0030674protein binding, bridging
CCIMPGO:0005886plasma membrane
CCIMPGO:0005938cell cortex
CCIDAGO:0032991protein-containing complex
CCIMPGO:0032991protein-containing complex
BPIEAGO:0007399nervous system development
BPIEAGO:0030154cell differentiation
BPIDAGO:0031647regulation of protein stability

Gene expression in normal tissue: INSC

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in INSC


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD491TAE-6841

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in INSC

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