IQGAP1
Summary: This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| IQ motif containing GTPase activating protein 1 | MIM:603379 | Ensembl:ENSG00000140575 | HGNC:HGNC:6110 | PA29910 | 15q26.1 |
GO terms in IQGAP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0001726 | ruffle |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005874 | microtubule |
| CC | TAS | GO:0005884 | actin filament |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | ISS | GO:0015629 | actin cytoskeleton |
| CC | ISS | GO:0015630 | microtubule cytoskeleton |
| CC | IEA | GO:0016328 | lateral plasma membrane |
| CC | ISS | GO:0030424 | axon |
| CC | ISS | GO:0030426 | growth cone |
| CC | IDA | GO:0030496 | midbody |
| CC | TAS | GO:0030667 | secretory granule membrane |
| CC | IDA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | ISS | GO:0036057 | slit diaphragm |
| CC | IDA | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| CC | ISS | GO:0043005 | neuron projection |
| CC | IEA | GO:0045121 | membrane raft |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0001817 | regulation of cytokine production |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IMP | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | IMP | GO:0007346 | regulation of mitotic cell cycle |
| BP | IEA | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IEA | GO:0034260 | negative regulation of GTPase activity |
| BP | IEA | GO:0035305 | negative regulation of dephosphorylation |
| BP | IEA | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | IMP | GO:0045860 | positive regulation of protein kinase activity |
| BP | IEA | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| BP | IEA | GO:0051894 | positive regulation of focal adhesion assembly |
| BP | IDA | GO:0071277 | cellular response to calcium ion |
| BP | IMP | GO:0071364 | cellular response to epidermal growth factor stimulus |
| BP | ISS | GO:0072015 | glomerular visceral epithelial cell development |
| BP | IEA | GO:1900006 | positive regulation of dendrite development |
| BP | IEA | GO:1900086 | positive regulation of peptidyl-tyrosine autophosphorylation |
| BP | IEA | GO:1903829 | positive regulation of cellular protein localization |
| BP | IEA | GO:1904754 | positive regulation of vascular associated smooth muscle cell migration |
| BP | IMP | GO:1990138 | neuron projection extension |
| BP | IEA | GO:1990776 | response to angiotensin |
| MF | TAS | GO:0005095 | GTPase inhibitor activity |
| MF | TAS | GO:0005096 | GTPase activator activity |
| MF | TAS | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005516 | calmodulin binding |
| MF | IDA | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0019903 | protein phosphatase binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IDA | GO:0043539 | protein serine/threonine kinase activator activity |
| MF | IPI | GO:0044548 | S100 protein binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IEA | GO:0048365 | Rac GTPase binding |
| MF | IEA | GO:0051019 | mitogen-activated protein kinase binding |
Gene expression in normal tissue: IQGAP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IQGAP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP524 | G13 Signaling Pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | ecadherin_nascentaj_pathway | E-cadherin signaling in the nascent adherens junction |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | ilk_pathway | Integrin-linked kinase signaling |
| pid | lis1pathway | Lissencephaly gene (LIS1) in neuronal migration and development |
| pid | nectin_pathway | Nectin adhesion pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | rac1_pathway | RAC1 signaling pathway |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-373753 | Nephrin family interactions |
| reactome | R-HSA-381676 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
| reactome | R-HSA-5626467 | RHO GTPases activate IQGAPs |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5674135 | MAP2K and MAPK activation |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants |
| reactome | R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants |
| reactome | R-HSA-6802949 | Signaling by RAS mutants |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IQGAP1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.