IQGAP2


Summary: This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
IQ motif containing GTPase activating protein 2MIM:605401Ensembl:ENSG00000145703HGNC:HGNC:6111PA299115q13.3

Gene Categories:

CELL SURFACE

GO terms in IQGAP2


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003779actin binding
MFTASGO:0005095GTPase inhibitor activity
MFIPIGO:0005515protein binding
MFIPIGO:0005516calmodulin binding
MFIDAGO:0005547phosphatidylinositol-3,4,5-trisphosphate binding
MFIDAGO:0017048Rho GTPase binding
MFIDAGO:0048365Rac GTPase binding
MFIDAGO:0051015actin filament binding
MFIDAGO:0071933Arp2/3 complex binding
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCIEAGO:0005902microvillus
CCIDAGO:0009986cell surface
CCTASGO:0015629actin cytoskeleton
CCIDAGO:0030027lamellipodium
CCIDAGO:0030175filopodium
CCTASGO:0030667secretory granule membrane
CCIDAGO:0031941filamentous actin
CCHDAGO:0070062extracellular exosome
BPTASGO:0007165signal transduction
BPIEAGO:0034260negative regulation of GTPase activity
BPIDAGO:0034314Arp2/3 complex-mediated actin nucleation
BPTASGO:0043312neutrophil degranulation
BPIDAGO:0070493thrombin-activated receptor signaling pathway

Gene expression in normal tissue: IQGAP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IQGAP2


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-5626467RHO GTPases activate IQGAPs
reactomeR-HSA-6798695Neutrophil degranulation
wikipathwaysWP524G13 Signaling Pathway
netpathPathway_TNFalphaTNFalpha
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD491TAE-6841

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IQGAP2

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