Summary: The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017].

iron responsive element binding protein 2MIM:147582Ensembl:ENSG00000136381HGNC:HGNC:6115PA2991415q25.1

GO terms in IREB2

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006826iron ion transport
BPTASGO:0006879cellular iron ion homeostasis
BPIEAGO:0008152metabolic process
BPIEAGO:0017148negative regulation of translation
MFIDAGO:0003723RNA binding
MFTASGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFTASGO:0030350iron-responsive element binding
MFIEAGO:0030371translation repressor activity
MFIEAGO:0046872metal ion binding
MFIEAGO:00515394 iron, 4 sulfur cluster binding

Gene expression in normal tissue: IREB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IREB2

DatabasePathway IDPathway Des.
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-917937Iron uptake and transport
wikipathwaysWP2007Iron metabolism in placenta
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IREB2