IRF8
Summary: Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interferon regulatory factor 8 | MIM:601565 | Ensembl:ENSG00000140968 | HGNC:HGNC:5358 | PA29606 | 16q24.1 |
GO terms in IRF8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | TAS | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding |
| MF | IPI | GO:0005515 | protein binding |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006909 | phagocytosis |
| BP | TAS | GO:0006955 | immune response |
| BP | IEA | GO:0030099 | myeloid cell differentiation |
| BP | IEA | GO:0032729 | positive regulation of interferon-gamma production |
| BP | IEA | GO:0032735 | positive regulation of interleukin-12 production |
| BP | IEA | GO:0042742 | defense response to bacterium |
| BP | IEA | GO:0042832 | defense response to protozoan |
| BP | IEA | GO:0044130 | negative regulation of growth of symbiont in host |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | TAS | GO:0060337 | type I interferon signaling pathway |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IDA | GO:0071346 | cellular response to interferon-gamma |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: IRF8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IRF8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| pid | gmcsf_pathway | GMCSF-mediated signaling events |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP3892 | Development of pulmonary dendritic cells and macrophage subsets |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IRF8
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