KCNB2


Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
potassium voltage-gated channel subfamily B member 2MIM:607738Ensembl:ENSG00000182674HGNC:HGNC:6232PA300258q21.11

GO terms in KCNB2


Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0006813potassium ion transport
BPTASGO:0006940regulation of smooth muscle contraction
BPIEAGO:0034765regulation of ion transmembrane transport
BPIEAGO:0051260protein homooligomerization
BPIBAGO:0071805potassium ion transmembrane transport
BPISSGO:0071805potassium ion transmembrane transport
BPISSGO:0072659protein localization to plasma membrane
CCISSGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0008076voltage-gated potassium channel complex
CCISSGO:0008076voltage-gated potassium channel complex
CCIBAGO:0016021integral component of membrane
CCIBAGO:0030425dendrite
CCISSGO:0030425dendrite
CCISSGO:0032809neuronal cell body membrane
CCIBAGO:0043025neuronal cell body
CCIEAGO:0043204perikaryon
MFIBAGO:0005249voltage-gated potassium channel activity
MFIBAGO:0005251delayed rectifier potassium channel activity
MFISSGO:0005251delayed rectifier potassium channel activity
MFISSGO:0046982protein heterodimerization activity

Gene expression in normal tissue: KCNB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNB2


DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-1296072Voltage gated Potassium channels

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012
iGMDRD30917AAG1
iGMDRD399Selumetinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNB2

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