KCNB2
Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium voltage-gated channel subfamily B member 2 | MIM:607738 | Ensembl:ENSG00000182674 | HGNC:HGNC:6232 | PA30025 | 8q21.11 |
GO terms in KCNB2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0006813 | potassium ion transport |
| BP | TAS | GO:0006940 | regulation of smooth muscle contraction |
| BP | IEA | GO:0034765 | regulation of ion transmembrane transport |
| BP | IEA | GO:0051260 | protein homooligomerization |
| BP | IBA | GO:0071805 | potassium ion transmembrane transport |
| BP | ISS | GO:0071805 | potassium ion transmembrane transport |
| BP | ISS | GO:0072659 | protein localization to plasma membrane |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0008076 | voltage-gated potassium channel complex |
| CC | ISS | GO:0008076 | voltage-gated potassium channel complex |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0030425 | dendrite |
| CC | ISS | GO:0030425 | dendrite |
| CC | ISS | GO:0032809 | neuronal cell body membrane |
| CC | IBA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0043204 | perikaryon |
| MF | IBA | GO:0005249 | voltage-gated potassium channel activity |
| MF | IBA | GO:0005251 | delayed rectifier potassium channel activity |
| MF | ISS | GO:0005251 | delayed rectifier potassium channel activity |
| MF | ISS | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: KCNB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNB2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296071 | Potassium Channels |
| reactome | R-HSA-1296072 | Voltage gated Potassium channels |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD399 | Selumetinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNB2
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