KCNIP3
Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium voltage-gated channel interacting protein 3 | MIM:604662 | Ensembl:ENSG00000115041 | HGNC:HGNC:15523 | PA26934 | 2q11.1 |
GO terms in KCNIP3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006886 | intracellular protein transport |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0071805 | potassium ion transmembrane transport |
| BP | ISS | GO:0072659 | protein localization to plasma membrane |
| BP | ISS | GO:1901379 | regulation of potassium ion transmembrane transport |
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0008076 | voltage-gated potassium channel complex |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0032993 | protein-DNA complex |
| CC | IEA | GO:0043679 | axon terminus |
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | TAS | GO:0003714 | transcription corepressor activity |
| MF | IEA | GO:0005244 | voltage-gated ion channel activity |
| MF | IEA | GO:0005267 | potassium channel activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0015459 | potassium channel regulator activity |
| MF | IEA | GO:0044325 | ion channel binding |
Gene expression in normal tissue: KCNIP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNIP3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5576894 | Phase 1 - inactivation of fast Na+ channels |
| biocarta | dreampathway | repression of pain sensation by the transcriptional regulator dream |
| netpath | Pathway_IL3 | IL3 |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNIP3
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