KCNIP3


Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

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Gene Categories:

ION CHANNELTRANSPORTER

GO terms in KCNIP3


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0000122 negative regulation of transcription by RNA polymerase II
BP IEA GO:0006351 transcription, DNA-templated
BP TAS GO:0006357 regulation of transcription by RNA polymerase II
BP IEA GO:0006886 intracellular protein transport
BP IEA GO:0006915 apoptotic process
BP TAS GO:0007165 signal transduction
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Gene expression in normal tissue: KCNIP3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNIP3


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Database
Pathway ID
Pathway Des.
reactome R-HSA-397014 Muscle contraction
reactome R-HSA-5576891 Cardiac conduction
reactome R-HSA-5576894 Phase 1 - inactivation of fast Na+ channels
biocarta dreampathway repression of pain sensation by the transcriptional regulator dream
netpath Pathway_IL3 IL3
wikipathways WP2032 Human Thyroid Stimulating Hormone (TSH) signaling pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
iGMDRD131 Erlotinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNIP3

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Cancer
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No matching records found

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