KCNIP3
Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:604662 Ensembl IDEnsembl:ENSG00000115041 HGNC IDHGNC:HGNC:15523 PHARMGKB IDPA26934 Map Location2q11.1 |
GO terms in KCNIP3
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
BP | IEA | GO:0006351 | transcription, DNA-templated |
BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
BP | IEA | GO:0006886 | intracellular protein transport |
BP | IEA | GO:0006915 | apoptotic process |
BP | TAS | GO:0007165 | signal transduction |
Gene expression in normal tissue: KCNIP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNIP3
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-397014 | Muscle contraction |
reactome | R-HSA-5576891 | Cardiac conduction |
reactome | R-HSA-5576894 | Phase 1 - inactivation of fast Na+ channels |
biocarta | dreampathway | repression of pain sensation by the transcriptional regulator dream |
netpath | Pathway_IL3 | IL3 |
wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in KCNIP3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |