KCNJ5
Summary: This gene encodes an integral membrane protein which belongs to one of seven subfamilies of inward-rectifier potassium channel proteins called potassium channel subfamily J. The encoded protein is a subunit of the potassium channel which is homotetrameric. It is controlled by G-proteins and has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Naturally occurring mutations in this gene are associated with aldosterone-producing adenomas. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium voltage-gated channel subfamily J member 5 | MIM:600734 | Ensembl:ENSG00000120457 | HGNC:HGNC:6266 | PA216 | 11q24.3 |
GO terms in KCNJ5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005242 | inward rectifier potassium channel activity |
| MF | IDA | GO:0005242 | inward rectifier potassium channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015467 | G-protein activated inward rectifier potassium channel activity |
| MF | IMP | GO:0086089 | voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization |
| MF | IC | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0008076 | voltage-gated potassium channel complex |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | IEA | GO:0030315 | T-tubule |
| BP | TAS | GO:0006813 | potassium ion transport |
| BP | IBA | GO:0010107 | potassium ion import |
| BP | IDA | GO:0010107 | potassium ion import |
| BP | IBA | GO:0034765 | regulation of ion transmembrane transport |
| BP | IEA | GO:0034765 | regulation of ion transmembrane transport |
| BP | IMP | GO:0086091 | regulation of heart rate by cardiac conduction |
| BP | IMP | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential |
| BP | IEA | GO:0098915 | membrane repolarization during ventricular cardiac muscle cell action potential |
| BP | IC | GO:0099625 | ventricular cardiac muscle cell membrane repolarization |
| BP | IDA | GO:1990573 | potassium ion import across plasma membrane |
Gene expression in normal tissue: KCNJ5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNJ5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296041 | Activation of G protein gated Potassium channels |
| reactome | R-HSA-1296059 | G protein gated Potassium channels |
| reactome | R-HSA-1296065 | Inwardly rectifying K+ channels |
| reactome | R-HSA-1296071 | Potassium Channels |
| reactome | R-HSA-977443 | GABA receptor activation |
| reactome | R-HSA-977444 | GABA B receptor activation |
| reactome | R-HSA-991365 | Activation of GABAB receptors |
| reactome | R-HSA-997272 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| smpdb | SMP00296 | Acebutolol Action Pathway |
| smpdb | SMP00297 | Alprenolol Action Pathway |
| smpdb | SMP00298 | Atenolol Action Pathway |
| smpdb | SMP00299 | Betaxolol Action Pathway |
| smpdb | SMP00300 | Bisoprolol Action Pathway |
| smpdb | SMP00301 | Esmolol Action Pathway |
| smpdb | SMP00302 | Metoprolol Action Pathway |
| smpdb | SMP00303 | Nadolol Action Pathway |
| smpdb | SMP00304 | Oxprenolol Action Pathway |
| smpdb | SMP00305 | Penbutolol Action Pathway |
| smpdb | SMP00306 | Pindolol Action Pathway |
| smpdb | SMP00307 | Propranolol Action Pathway |
| smpdb | SMP00323 | Quinidine Action Pathway |
| smpdb | SMP00324 | Procainamide (Antiarrhythmic) Action Pathway |
| smpdb | SMP00325 | Disopyramide Action Pathway |
| smpdb | SMP00326 | Fosphenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00327 | Phenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00328 | Lidocaine (Antiarrhythmic) Action Pathway |
| smpdb | SMP00329 | Mexiletine Action Pathway |
| smpdb | SMP00330 | Tocainide Action Pathway |
| smpdb | SMP00331 | Flecainide Action Pathway |
| smpdb | SMP00332 | Ibutilide Action Pathway |
| smpdb | SMP00359 | Diltiazem Action Pathway |
| smpdb | SMP00366 | Nebivolol Action Pathway |
| smpdb | SMP00367 | Carvedilol Action Pathway |
| smpdb | SMP00368 | Labetalol Action Pathway |
| smpdb | SMP00375 | Verapamil Action Pathway |
| smpdb | SMP00376 | Amlodipine Action Pathway |
| smpdb | SMP00377 | Felodipine Action Pathway |
| smpdb | SMP00378 | Isradipine Action Pathway |
| smpdb | SMP00379 | Nifedipine Action Pathway |
| smpdb | SMP00380 | Nimodipine Action Pathway |
| smpdb | SMP00381 | Nisoldipine Action Pathway |
| smpdb | SMP00382 | Nitrendipine Action Pathway |
| smpdb | SMP00588 | Muscle/Heart Contraction |
| smpdb | SMP00657 | Bopindolol Action Pathway |
| smpdb | SMP00658 | Carteolol Action Pathway |
| smpdb | SMP00659 | Timolol Action Pathway |
| smpdb | SMP00660 | Sotalol Action Pathway |
| smpdb | SMP00661 | Epinephrine Action Pathway |
| smpdb | SMP00662 | Dobutamine Action Pathway |
| smpdb | SMP00663 | Isoprenaline Action Pathway |
| smpdb | SMP00664 | Arbutamine Action Pathway |
| smpdb | SMP00665 | Amiodarone Action Pathway |
| smpdb | SMP00666 | Levobunolol Action Pathway |
| smpdb | SMP00667 | Metipranolol Action Pathway |
| smpdb | SMP00668 | Bevantolol Action Pathway |
| smpdb | SMP00669 | Practolol Action Pathway |
| smpdb | SMP00670 | Bupranolol Action Pathway |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa05032 | Morphine addiction - Homo sapiens (human) |
| pharmgkb | PA2033 | Antiarrhythmic Pathway, Pharmacodynamics |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD91 | (R)-Verapamil | 1 |
| iGMDRD59 | Amiloride | 1 |
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNJ5
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.