KCNK1


Summary: This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
potassium two pore domain channel subfamily K member 1MIM:601745Ensembl:ENSG00000135750HGNC:HGNC:6272PA2191q42.2

GO terms in KCNK1


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCISSGO:0005887integral component of plasma membrane
CCTASGO:0008076voltage-gated potassium channel complex
CCIDAGO:0016021integral component of membrane
CCIEAGO:0016324apical plasma membrane
CCIEAGO:0030054cell junction
CCIEAGO:0030425dendrite
CCIEAGO:0031526brush border membrane
CCIDAGO:0034705potassium channel complex
CCIEAGO:0043204perikaryon
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIEAGO:0045202synapse
CCIEAGO:0055037recycling endosome
CCIEAGO:1902937inward rectifier potassium channel complex
BPTASGO:0006813potassium ion transport
BPIBAGO:0030322stabilization of membrane potential
BPIEAGO:0035094response to nicotine
BPIDAGO:0035725sodium ion transmembrane transport
BPIMPGO:0060075regulation of resting membrane potential
BPTASGO:0061337cardiac conduction
BPIBAGO:0071805potassium ion transmembrane transport
BPIDAGO:0071805potassium ion transmembrane transport
MFTASGO:0005242inward rectifier potassium channel activity
MFIDAGO:0005249voltage-gated potassium channel activity
MFIDAGO:0005267potassium channel activity
MFTASGO:0005267potassium channel activity
MFIDAGO:0005272sodium channel activity
MFIPIGO:0005515protein binding
MFIBAGO:0022841potassium ion leak channel activity
MFIDAGO:0022841potassium ion leak channel activity
MFIPIGO:0042802identical protein binding

Gene expression in normal tissue: KCNK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNK1


DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-1296346Tandem pore domain potassium channels
reactomeR-HSA-1299308Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-5576886Phase 4 - resting membrane potential
reactomeR-HSA-5576891Cardiac conduction
pharmgkbPA2033Antiarrhythmic Pathway, Pharmacodynamics
smpdbSMP00296Acebutolol Action Pathway
smpdbSMP00297Alprenolol Action Pathway
smpdbSMP00298Atenolol Action Pathway
smpdbSMP00299Betaxolol Action Pathway
smpdbSMP00300Bisoprolol Action Pathway
smpdbSMP00301Esmolol Action Pathway
smpdbSMP00302Metoprolol Action Pathway
smpdbSMP00303Nadolol Action Pathway
smpdbSMP00304Oxprenolol Action Pathway
smpdbSMP00305Penbutolol Action Pathway
smpdbSMP00306Pindolol Action Pathway
smpdbSMP00307Propranolol Action Pathway
smpdbSMP00323Quinidine Action Pathway
smpdbSMP00324Procainamide (Antiarrhythmic) Action Pathway
smpdbSMP00325Disopyramide Action Pathway
smpdbSMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00327Phenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00328Lidocaine (Antiarrhythmic) Action Pathway
smpdbSMP00329Mexiletine Action Pathway
smpdbSMP00330Tocainide Action Pathway
smpdbSMP00331Flecainide Action Pathway
smpdbSMP00332Ibutilide Action Pathway
smpdbSMP00359Diltiazem Action Pathway
smpdbSMP00366Nebivolol Action Pathway
smpdbSMP00367Carvedilol Action Pathway
smpdbSMP00368Labetalol Action Pathway
smpdbSMP00375Verapamil Action Pathway
smpdbSMP00376Amlodipine Action Pathway
smpdbSMP00377Felodipine Action Pathway
smpdbSMP00378Isradipine Action Pathway
smpdbSMP00379Nifedipine Action Pathway
smpdbSMP00380Nimodipine Action Pathway
smpdbSMP00381Nisoldipine Action Pathway
smpdbSMP00382Nitrendipine Action Pathway
smpdbSMP00588Muscle/Heart Contraction
smpdbSMP00657Bopindolol Action Pathway
smpdbSMP00658Carteolol Action Pathway
smpdbSMP00659Timolol Action Pathway
smpdbSMP00660Sotalol Action Pathway
smpdbSMP00661Epinephrine Action Pathway
smpdbSMP00662Dobutamine Action Pathway
smpdbSMP00663Isoprenaline Action Pathway
smpdbSMP00664Arbutamine Action Pathway
smpdbSMP00665Amiodarone Action Pathway
smpdbSMP00666Levobunolol Action Pathway
smpdbSMP00667Metipranolol Action Pathway
smpdbSMP00668Bevantolol Action Pathway
smpdbSMP00669Practolol Action Pathway
smpdbSMP00670Bupranolol Action Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD131Erlotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNK1

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