KCNMA1
Summary: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium calcium-activated channel subfamily M alpha 1 | MIM:600150 | Ensembl:ENSG00000156113 | HGNC:HGNC:6284 | PA220 | 10q22.3 |
GO terms in KCNMA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0001666 | response to hypoxia |
| BP | IDA | GO:0006813 | potassium ion transport |
| BP | IDA | GO:0006970 | response to osmotic stress |
| BP | IDA | GO:0030007 | cellular potassium ion homeostasis |
| BP | IDA | GO:0034465 | response to carbon monoxide |
| BP | IMP | GO:0034465 | response to carbon monoxide |
| BP | IEA | GO:0034765 | regulation of ion transmembrane transport |
| BP | IBA | GO:0042391 | regulation of membrane potential |
| BP | IDA | GO:0042391 | regulation of membrane potential |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0045794 | negative regulation of cell volume |
| BP | IDA | GO:0051592 | response to calcium ion |
| BP | IDA | GO:0060073 | micturition |
| BP | IDA | GO:0060083 | smooth muscle contraction involved in micturition |
| BP | IEA | GO:0071805 | potassium ion transmembrane transport |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005901 | caveola |
| CC | IDA | GO:0008076 | voltage-gated potassium channel complex |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | IBA | GO:0045211 | postsynaptic membrane |
| MF | IDA | GO:0003779 | actin binding |
| MF | IDA | GO:0005249 | voltage-gated potassium channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0015269 | calcium-activated potassium channel activity |
| MF | IDA | GO:0015269 | calcium-activated potassium channel activity |
| MF | IBA | GO:0015271 | outward rectifier potassium channel activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IBA | GO:0060072 | large conductance calcium-activated potassium channel activity |
| MF | IDA | GO:0060072 | large conductance calcium-activated potassium channel activity |
| MF | IMP | GO:0060072 | large conductance calcium-activated potassium channel activity |
Gene expression in normal tissue: KCNMA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNMA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296052 | Ca2+ activated K+ channels |
| reactome | R-HSA-1296071 | Potassium Channels |
| reactome | R-HSA-392154 | Nitric oxide stimulates guanylate cyclase |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418457 | cGMP effects |
| wikipathways | WP4148 | Splicing factor NOVA regulated synaptic proteins |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| kegg | hsa04972 | Pancreatic secretion - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNMA1
CLASSFICATION
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