KCNMB3


Summary: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
potassium calcium-activated channel subfamily M regulatory beta subunit 3MIM:605222Ensembl:ENSG00000171121HGNC:HGNC:6287PA300673q26.32

Gene Categories:

ION CHANNELTRANSPORTER

GO terms in KCNMB3


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0015269calcium-activated potassium channel activity
MFIDAGO:0015269calcium-activated potassium channel activity
MFIBAGO:0015459potassium channel regulator activity
MFNASGO:0015459potassium channel regulator activity
CCTASGO:0005886plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIBAGO:0008076voltage-gated potassium channel complex
CCIDAGO:0008076voltage-gated potassium channel complex
BPIDAGO:0001508action potential
BPIBAGO:0005513detection of calcium ion
BPIDAGO:0005513detection of calcium ion
BPIDAGO:0006813potassium ion transport
BPIDAGO:0019228neuronal action potential
BPIEAGO:0071805potassium ion transmembrane transport

Gene expression in normal tissue: KCNMB3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNMB3


DatabasePathway IDPathway Des.
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296052Ca2+ activated K+ channels
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-392154Nitric oxide stimulates guanylate cyclase
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418457cGMP effects

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib1
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNMB3

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