KCNN3
Summary: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium calcium-activated channel subfamily N member 3 | MIM:602983 | Ensembl:ENSG00000143603 | HGNC:HGNC:6292 | PA30072 | 1q21.3 |
GO terms in KCNN3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IBA | GO:0016286 | small conductance calcium-activated potassium channel activity |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043025 | neuronal cell body |
| BP | IBA | GO:0071805 | potassium ion transmembrane transport |
| BP | IEA | GO:0071805 | potassium ion transmembrane transport |
Gene expression in normal tissue: KCNN3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNN3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296052 | Ca2+ activated K+ channels |
| reactome | R-HSA-1296071 | Potassium Channels |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNN3
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