KEAP1
Summary: This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| kelch like ECH associated protein 1 | MIM:606016 | Ensembl:ENSG00000079999 | HGNC:HGNC:23177 | PA134887774 | 19p13.2 |
GO terms in KEAP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0097718 | disordered domain specific binding |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005884 | actin filament |
| CC | IDA | GO:0030496 | midbody |
| CC | IDA | GO:0031463 | Cul3-RING ubiquitin ligase complex |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | TAS | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IBA | GO:0042994 | cytoplasmic sequestering of transcription factor |
| BP | TAS | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | IEA | GO:0045604 | regulation of epidermal cell differentiation |
| BP | IEA | GO:0071353 | cellular response to interleukin-4 |
Gene expression in normal tissue: KEAP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KEAP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8951664 | Neddylation |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| biocarta | arenrf2pathway | oxidative stress induced gene expression via nrf2 |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| wikipathways | WP2435 | Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP3 | Transcriptional activation by NRF2 |
| wikipathways | WP3612 | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| wikipathways | WP3953 | mRNA, protein, and metabolite inducation pathway by cyclosporin A |
| wikipathways | WP4206 | Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD588 | HG-5-88-01 | 1 |
| iGMDRD232 | FTI-277 | 1 |
| iGMDRD396 | AS601245 | 1 |
| iGMDRD218 | XAV 939 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KEAP1
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