KEAP1


Summary: This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
kelch like ECH associated protein 1MIM:606016Ensembl:ENSG00000079999HGNC:HGNC:23177PA13488777419p13.2

GO terms in KEAP1


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIBAGO:0008134transcription factor binding
MFIPIGO:0008134transcription factor binding
MFIEAGO:0042803protein homodimerization activity
MFIEAGO:0097718disordered domain specific binding
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIEAGO:0005783endoplasmic reticulum
CCIDAGO:0005815microtubule organizing center
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0005884actin filament
CCIDAGO:0030496midbody
CCIDAGO:0031463Cul3-RING ubiquitin ligase complex
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0006351transcription, DNA-templated
BPIDAGO:0010499proteasomal ubiquitin-independent protein catabolic process
BPIDAGO:0016567protein ubiquitination
BPIEAGO:0016567protein ubiquitination
BPTASGO:0016579protein deubiquitination
BPTASGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BPIBAGO:0042994cytoplasmic sequestering of transcription factor
BPTASGO:0043433negative regulation of DNA-binding transcription factor activity
BPTASGO:0043687post-translational protein modification
BPIEAGO:0045604regulation of epidermal cell differentiation
BPIEAGO:0071353cellular response to interleukin-4

Gene expression in normal tissue: KEAP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KEAP1


DatabasePathway IDPathway Des.
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8951664Neddylation
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
biocartaarenrf2pathwayoxidative stress induced gene expression via nrf2
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
wikipathwaysWP2435Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP3Transcriptional activation by NRF2
wikipathwaysWP3612Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling
wikipathwaysWP3953mRNA, protein, and metabolite inducation pathway by cyclosporin A
wikipathwaysWP4206Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD588HG-5-88-011
iGMDRD232FTI-2771
iGMDRD396AS6012451
iGMDRD218XAV 9391

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KEAP1

​​​​